Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 17/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1087769 | 0.91 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL1089016 | 0.89 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL1088337 | 0.89 | PIK3CD (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL1865372 | 0.88 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL1088049 | 0.86 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL1088461 | 0.86 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2943000 | 0.86 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL390035 | 0.85 | PIK3CD (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL1087908 | 0.84 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL3622005 | 0.84 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2518074-B1 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | HOFFMANN LA ROCHE (CH) | 2015-07-22 | — | — | EP | disclosed |
| EP-2518074-A1 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | F. Hoffmann-La Roche AG (CH) | 2012-10-31 | — | — | EP | disclosed |
| EP-2114949-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |