Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3078972 | 0.87 | PDE4D (0.56) | KMT2APDE4DHCAR2KDM4EL3MBTL1 | |
| SCHEMBL1665229 | 0.85 | DAO (0.58) | KMT2APDE4DDAOHCAR2NPSR1 | |
| SCHEMBL17593217 | 0.76 | KMT2A (0.52) | KMT2APDE4DKDM4ENPSR1L3MBTL1 | |
| SCHEMBL20525148 | 0.74 | KMT2A (0.50) | KMT2APDE4DHCAR2NPSR1L3MBTL1 | |
| SCHEMBL1233899 | 0.73 | HCAR2 (0.64) | KMT2APDE4DHCAR2NPSR1L3MBTL1 | |
| SCHEMBL19253412 | 0.73 | MAPT (0.55) | KMT2APDE4DKDM4EMAPTPOLB | |
| SCHEMBL25466120 | 0.73 | HCAR2 (0.50) | KMT2APDE4DDAOHCAR2NPSR1 | |
| SCHEMBL20298373 | 0.73 | MAPT (0.50) | KMT2APDE4DKDM4ENPSR1L3MBTL1 | |
| SCHEMBL7705757 | 0.72 | HCAR2 (0.59) | KMT2APDE4DHCAR2NPSR1L3MBTL1 | |
| SCHEMBL1233339 | 0.71 | KMT2A (0.48) | KMT2APDE4DHCAR2KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134684-A2 | 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS | Abbott Laboratories (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008131000-A2 | 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS | ABBOTT LABORATORIES (US) | 2008-10-30 | — | — | WO | disclosed |