Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPLP1 | P05386 | 12/20 | 0.36 |
| ▸ | RPLP0 | P05388 | 12/20 | 0.36 |
| ▸ | RPS17 | P08708 | 12/20 | 0.36 |
| ▸ | RPSA | P08865 | 12/20 | 0.36 |
| ▸ | RPS2 | P15880 | 12/20 | 0.36 |
| ▸ | RPL35A | P18077 | 12/20 | 0.36 |
| ▸ | RPL7 | P18124 | 12/20 | 0.36 |
| ▸ | RPL17 | P18621 | 12/20 | 0.36 |
| ▸ | RPS4Y1 | P22090 | 12/20 | 0.36 |
| ▸ | RPS3 | P23396 | 12/20 | 0.36 |
| ▸ | RPS12 | P25398 | 12/20 | 0.36 |
| ▸ | RPL13 | P26373 | 12/20 | 0.36 |
| ▸ | RPL10 | P27635 | 12/20 | 0.36 |
| ▸ | RPL12 | P30050 | 12/20 | 0.36 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 12/20 | 0.36 |
| ▸ | RPL22 | P35268 | 12/20 | 0.36 |
| ▸ | RPL4 | P36578 | 12/20 | 0.36 |
| ▸ | RPS19 | P39019 | 12/20 | 0.36 |
| ▸ | RPL3 | P39023 | 12/20 | 0.36 |
| ▸ | RPL13A | P40429 | 12/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410672 | 1.00 | RPLP1 (0.36) | RPLP1RPLP0RPS17RPSARPS2 | |
| SCHEMBL3410670 | 1.00 | RPLP1 (0.36) | RPLP1RPLP0RPS17RPSARPS2 | |
| SCHEMBL4439873 | 0.94 | SLC6A4 (0.36) | KCNH2 | |
| SCHEMBL4445128 | 0.92 | RPLP1 (0.36) | RPLP1RPLP0RPS17RPSARPS2 | |
| SCHEMBL3412017 | 0.84 | RPLP1 (0.41) | RPLP1RPLP0RPS17RPSARPS2 | |
| SCHEMBL3412292 | 0.84 | RPLP1 (0.35) | RPLP1RPLP0RPS17RPSARPS2 | |
| SCHEMBL3412297 | 0.84 | RPLP1 (0.35) | RPLP1RPLP0RPS17RPSARPS2 | |
| SCHEMBL4443619 | 0.84 | RPLP1 (0.35) | RPLP1RPLP0RPS17RPSARPS2 | |
| SCHEMBL1710277 | 0.83 | NAMPT (0.33) | PCSK9 | |
| SCHEMBL4443673 | 0.82 | RPLP1 (0.34) | RPLP1RPLP0RPS17RPSARPS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |