⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28670350 | 0.98 | — | — | |
| SCHEMBL27674320 | 0.82 | — | — | |
| SCHEMBL28032704 | 0.82 | — | — | |
| SCHEMBL933257 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL21408262 | 0.78 | — | — | |
| SCHEMBL932027 | 0.78 | — | — | |
| SCHEMBL28323379 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL933127 | 0.77 | — | — | |
| Formaldehyde SCHEMBL27690920 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL27863821 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116867758-A | IRAK degradation agents and uses thereof | 凯麦拉医疗公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-116669722-A | Interleukin-1 receptor-related kinase (IRAK) degradants and uses thereof | 凯麦拉医疗公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-115925711-A | Substituted pyrazolo [1,5-a ] pyrimidines and their use in treating medical disorders | BIAL研发投资股份有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-107001379-B | Substituted pyrazolo [1,5-a ] pyrimidines and their use in the treatment of medical disorders | BIAL研发投资股份有限公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-110114343-B | Pyrazolopyrimidine compounds and methods of use thereof | 豪夫迈·罗氏有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-109890829-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-110494434-B | Pyrazolophenyl compounds, compositions thereof, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2022-05-24 | — | — | CN | disclosed |
| CN-109970743-B | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds as JAK inhibitors | 豪夫迈·罗氏有限公司 | 2022-03-04 | — | — | CN | disclosed |
| CN-110003209-B | Macrocyclic compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2022-01-25 | — | — | CN | disclosed |
| CN-108473498-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2021-11-02 | — | — | CN | disclosed |
| CN-105693720-A | Macrocyclic compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-102971322-B | Macrocyclic compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-02-17 | — | — | CN | disclosed |
| CN-102633745-B | Alpha-methoxy imino group-4-methyl-1, 2, 3-thiadiazole-5-methyl carboxylic ester derivatives and preparation method and application thereof | UNIV NANKAI | 2014-06-18 | — | — | CN | disclosed |
| CN-102971322-A | Macrocyclic compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC | 2013-03-13 | — | — | CN | disclosed |
| CN-102633745-A | Alpha-methoxy imino group-4-methyl-1, 2, 3-thiadiazole-5-methyl carboxylic ester derivatives and preparation method and application thereof | UNIV NANKAI | 2012-08-15 | — | — | CN | disclosed |
| CN-101801972-A | Pyrazolo [1,5-A]pyrimidines as inhibitors of stearoyl-coA desaturase | INOVACIA AB | 2010-08-11 | — | — | CN | disclosed |
| EP-2137187-A1 | PYRAZOLO [1,5-A]PYRIMIDINES AS INHIBITORS OF STEAROYL-COA DESATURASE | Inovacia AB (SE) | 2009-12-30 | — | — | EP | disclosed |
| CN-100528876-C | Pyrrazolo-pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2009-08-19 | — | — | CN | disclosed |
| WO-2008116898-A1 | PYRAZOLO [1,5-A]PYRIMIDINES AS INHIBITORS OF STEAROYL-COA DESATURASE | BIOVITRUM AB (PUBL) (SE) | 2008-10-02 | — | — | WO | disclosed |
| CN-1964973-A | Pyrrazolo-pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2007-05-16 | — | — | CN | disclosed |