Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 9/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2195666 | 1.00 | IDH1 (0.35) | IDH1IGF1RACACBMAPK1FLT3 | |
| SCHEMBL2199735 | 0.91 | IDH1 (0.34) | IDH1IGF1RMAPK1FLT3 | |
| SCHEMBL2196962 | 0.88 | IGF1R (0.37) | IDH1IGF1RFLT3 | |
| SCHEMBL2199167 | 0.85 | IDH1 (0.36) | IDH1IGF1RACACB | |
| SCHEMBL2195698 | 0.85 | IGF1R (0.36) | IDH1IGF1R | |
| SCHEMBL2195588 | 0.83 | IGF1R (0.33) | IDH1IGF1RFLT3 | |
| SCHEMBL2196446 | 0.82 | IDH1 (0.35) | IDH1IGF1RMAPK1 | |
| SCHEMBL2198188 | 0.82 | IDH1 (0.35) | IDH1IGF1RMAPK1 | |
| SCHEMBL2196439 | 0.82 | IDH1 (0.35) | IDH1IGF1RMAPK1 | |
| SCHEMBL2197134 | 0.82 | IDH1 (0.35) | IDH1IGF1RMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114942-A1 | NOVEL AMINOPYRIMIDINE DERIVATIVES AS PLK1 INHIBITORS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-11-11 | — | — | EP | claimed |
| WO-2008081910-A1 | NOVEL AMINOPYRIMIDINE DERIVATIVES AS PLK1 INHIBITORS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-07-10 | — | — | WO | claimed |
| EP-2114942-A1 | NOVEL AMINOPYRIMIDINE DERIVATIVES AS PLK1 INHIBITORS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008081910-A1 | NOVEL AMINOPYRIMIDINE DERIVATIVES AS PLK1 INHIBITORS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-07-10 | — | — | WO | disclosed |