Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 20/20 | 0.60 |
| ▸ | CSNK2B | P67870 | 20/20 | 0.60 |
| ▸ | CDC7 | O00311 | 15/20 | 0.60 |
| ▸ | CSNK2A1 | P68400 | 15/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 10/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 10/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553095 | 0.92 | PIM1 (0.59) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL4552975 | 0.91 | PIM1 (0.58) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL4275559 | 0.90 | PIM1 (0.51) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1854350 | 0.85 | PIM1 (0.63) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1854292 | 0.85 | PIM1 (0.70) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1851552 | 0.84 | PIM1 (0.71) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1852450 | 0.83 | PIM1 (0.62) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1855006 | 0.83 | PIM1 (0.64) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1852557 | 0.82 | PIM1 (0.61) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL13787064 | 0.82 | PIM1 (0.63) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |