SCHEMBL4436769

SCHEMBL4436769

CCCCCCCC(NC(=O)OC1CCCC1)C(=O)OC

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 2/20 0.53
HDAC1 Q13547 2/20 0.53
NAAA Q02083 2/20 0.49
ZDHHC7 Q9NXF8 1/20 0.44
EPHX1 P07099 1/20 0.44
SIRT2 Q8IXJ6 1/20 0.42
SIRT1 Q96EB6 1/20 0.42
SIRT3 Q9NTG7 1/20 0.42
CTSK P43235 3/20 0.38
CTSV O60911 2/20 0.38
CTSL P07711 2/20 0.38
CTSS P25774 2/20 0.38
TAS1R3 Q7RTX0 3/20 0.38
TAS1R1 Q7RTX1 3/20 0.38
HDAC6 Q9UBN7 1/20 0.38
BIRC2 Q13490 2/20 0.38
TSHR P16473 1/20 0.37
ABCB1 P08183 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2807876 0.89 HDAC4 (0.53) HDAC4HDAC1NAAAEPHX1SIRT2
SCHEMBL2807880 0.89 HDAC4 (0.53) HDAC4HDAC1NAAAEPHX1SIRT2
SCHEMBL2805485 0.88 HDAC4 (0.52) HDAC4HDAC1NAAAZDHHC7EPHX1
SCHEMBL2805502 0.88 HDAC4 (0.52) HDAC4HDAC1EPHX1CTSKCTSV
SCHEMBL2805504 0.88 HDAC4 (0.52) HDAC4HDAC1EPHX1CTSKCTSV
SCHEMBL2805484 0.88 HDAC4 (0.52) HDAC4HDAC1NAAAZDHHC7EPHX1
SCHEMBL27780890 0.88 HDAC4 (0.54) HDAC4HDAC1NAAAEPHX1SIRT2
SCHEMBL2809542 0.87 HDAC4 (0.51) HDAC4HDAC1NAAAEPHX1SIRT2
SCHEMBL4442492 0.87 HDAC4 (0.51) HDAC4HDAC1NAAAEPHX1SIRT2
Hydrochloric Acid SCHEMBL4446986 0.86 HDAC4 (0.53) HDAC4HDAC1NAAAEPHX1SIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2125757-A1 MACROCYCLIC COMPOUNDS AS HCV NS3 PROTEASE INHIBITORS Novartis AG (CH) 2009-12-02 EP disclosed
WO-2008101665-A1 MACROCYCLIC COMPOUNDS AS HCV NS3 PROTEASE INHIBITORS NOVARTIS AG (CH) 2008-08-28 WO disclosed