Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.41 |
| ▸ | LIPC | P11150 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437026 | 1.00 | KMT2A (0.43) | KMT2AMEN1TSHRRXFP1LIPC | |
| SCHEMBL1826265 | 0.95 | KMT2A (0.44) | KMT2AMEN1TSHRRXFP1LIPC | |
| SCHEMBL1826247 | 0.95 | KMT2A (0.44) | KMT2AMEN1TSHRRXFP1LIPC | |
| SCHEMBL1824506 | 0.92 | KMT2A (0.44) | KMT2AMEN1KDM4E | |
| SCHEMBL1824507 | 0.92 | KMT2A (0.44) | KMT2AMEN1KDM4E | |
| SCHEMBL4437030 | 0.92 | KMT2A (0.42) | KMT2AMEN1TSHRRXFP1LMNA | |
| SCHEMBL1827461 | 0.87 | KMT2A (0.50) | KMT2AMEN1TSHRRXFP1LIPC | |
| SCHEMBL1827463 | 0.87 | KMT2A (0.50) | KMT2AMEN1TSHRRXFP1LIPC | |
| SCHEMBL1826584 | 0.86 | MEN1 (0.46) | KMT2AMEN1TSHRRXFP1LIPC | |
| SCHEMBL1826585 | 0.86 | MEN1 (0.46) | KMT2AMEN1TSHRRXFP1LIPC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118051-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | Chelsea Therapeutics, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008097180-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | CHELSEA THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |