Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 17/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 15/20 | 0.34 |
| ▸ | PIM1 | P11309 | 11/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438383 | 1.00 | PIM2 (0.34) | PIM2PIM3PIM1PDE10A | |
| SCHEMBL4434926 | 0.94 | PIM2 (0.34) | PIM2PIM3PIM1PDE10A | |
| SCHEMBL4444690 | 0.89 | PIM3 (0.37) | PIM2PIM3PIM1 | |
| SCHEMBL4435474 | 0.87 | PIM2 (0.49) | PIM2PIM3PIM1 | |
| SCHEMBL4436056 | 0.84 | PIM2 (0.38) | PIM2PIM3PIM1 | |
| SCHEMBL3411679 | 0.84 | PIM1 (0.40) | PIM2PIM3PIM1 | |
| SCHEMBL4439362 | 0.84 | PIM2 (0.34) | PIM2PIM3PIM1PDE10A | |
| SCHEMBL3411675 | 0.84 | PIM1 (0.40) | PIM2PIM3PIM1 | |
| SCHEMBL4437200 | 0.83 | PIM1 (0.38) | PIM2PIM3PIM1 | |
| SCHEMBL4439852 | 0.83 | PIM3 (0.37) | PIM2PIM3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |