Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.56 |
| ▸ | AKT1 | P31749 | 16/20 | 0.56 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 12/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL854981 | 0.77 | PIK3CA (0.67) | PIK3CAAKT1MAP3K12MTOR | |
| SCHEMBL854991 | 0.73 | PIK3CA (0.80) | PIK3CAAKT1MAP3K12MTOR | |
| SCHEMBL29923102 | 0.72 | PIK3CA (1.00) | PIK3CAAKT1MAP3K12MTOR | |
| SCHEMBL21469921 | 0.72 | PIK3CA (1.00) | PIK3CAAKT1MAP3K12MTOR | |
| SCHEMBL10327868 | 0.71 | PIK3CA (0.71) | PIK3CAAKT1MAP3K12MTOR | |
| SCHEMBL10327890 | 0.71 | PIK3CA (1.00) | PIK3CAAKT1MAP3K12MTOR | |
| SCHEMBL21464389 | 0.70 | PIK3CA (0.67) | PIK3CAAKT1MAP3K12MTOR | |
| SCHEMBL855550 | 0.70 | PIK3CA (0.74) | PIK3CAAKT1MAP3K12MTOR | |
| SCHEMBL10328179 | 0.69 | PIK3CA (0.74) | PIK3CAAKT1MAP3K12MTOR | |
| SCHEMBL1309681 | 0.69 | PIK3CA (0.71) | PIK3CAAKT1MAP3K12MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118087-A1 | PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098058-A1 | PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2008-08-14 | — | — | WO | disclosed |