SCHEMBL4437675

SCHEMBL4437675

CS(=O)(=O)CCC1CC(c2cccc(C(F)(F)F)c2)N(c2ccc(Oc3ccc(Cl)cc3)cc2)C1=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.37
MEN1 O00255 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
KMT2A Q03164 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
CETP P11597 1/20 0.35
CNR1 P21554 3/20 0.35
CNR2 P34972 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
MCHR1 Q99705 2/20 0.35
MMP2 P08253 1/20 0.34
MMP9 P14780 1/20 0.34
NPBWR1 P48145 2/20 0.33
TP53 P04637 1/20 0.33
MDM2 Q00987 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3585646 1.00 HTT (0.37) HTTMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL3586449 1.00 HTT (0.37) HTTMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL4439926 0.95 HTT (0.36) HTTMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL3593071 0.95 HTT (0.36) HTTMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL3595644 0.90 HTT (0.36) HTTMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL4438918 0.90 HTT (0.36) HTTMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL15181797 0.89 HTT (0.39) HTTMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL15181817 0.89 HTT (0.39) HTTMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL3596028 0.88 HTT (0.35) HTTMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL4441300 0.88 HTT (0.35) HTTMEN1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121598-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM LLC (BM) 2009-11-25 EP claimed
WO-2008076754-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM LLC (BM) 2008-06-26 WO claimed
EP-2121598-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM LLC (BM) 2009-11-25 EP disclosed
WO-2008076754-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM LLC (BM) 2008-06-26 WO disclosed