Sugi Predict

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SCHEMBL4437752

SCHEMBL4437752

Cc1ccccc1P(c1ccccc1C)c1ccccc1C.O=C(Nc1cccc(C(F)(F)F)c1)c1ccc(Cl)c(-c2ccc3c(c2)[nH]c2ncncc23)c1

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ LCK P06239 5/20 0.52
▸ DDR2 Q16832 14/20 0.50
▸ FGFR1 P11362 11/20 0.48
▸ MAPK14 Q16539 4/20 0.47
▸ KDR P35968 3/20 0.47
▸ JAK3 P52333 2/20 0.47
▸ TEK Q02763 2/20 0.47
▸ KIT P10721 2/20 0.46
▸ SRC P12931 2/20 0.46
▸ BRAF P15056 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2306827 0.91 LCK (0.61) LCKDDR2FGFR1MAPK14KDR
SCHEMBL2304975 0.87 DDR2 (0.65) LCKDDR2FGFR1MAPK14KDR
SCHEMBL2307402 0.85 DDR2 (0.65) LCKDDR2FGFR1MAPK14KDR
SCHEMBL2305092 0.82 DDR2 (0.58) LCKDDR2FGFR1MAPK14KDR
SCHEMBL2303547 0.81 DDR2 (0.51) LCKDDR2FGFR1MAPK14KDR
SCHEMBL2304084 0.81 DDR2 (0.65) LCKDDR2FGFR1MAPK14KDR
SCHEMBL2305579 0.81 DDR2 (0.63) LCKDDR2FGFR1MAPK14KDR
SCHEMBL2302007 0.80 LCK (0.58) LCKDDR2MAPK14KDRJAK3
SCHEMBL2305033 0.79 LCK (0.53) LCKDDR2MAPK14KDRTEK
SCHEMBL2304320 0.78 DDR2 (0.53) LCKDDR2FGFR1MAPK14KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121692-A1 SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS Incyte Corporation (US) 2009-11-25 — — EP disclosed
WO-2008079965-A1 SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS INCYTE CORPORATION (US) 2008-07-03 — — WO disclosed