Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | FABP7 | O15540 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1404235 | 0.91 | EPHX2 (0.46) | KMT2ADPP8DPP9EPHX2OPRD1 | |
| SCHEMBL3491022 | 0.90 | DPP8 (0.47) | KMT2ADPP8DPP9EPHX2OPRD1 | |
| SCHEMBL31515070 | 0.86 | BACE1 (0.46) | KMT2ADPP8DPP9EPHX2TSHR | |
| SCHEMBL5192807 | 0.86 | BACE1 (0.46) | KMT2ADPP8DPP9EPHX2TSHR | |
| SCHEMBL3088791 | 0.85 | KMT2A (0.44) | KMT2ADPP8DPP9EPHX2OPRD1 | |
| SCHEMBL3088787 | 0.85 | SMN1; SMN2 (0.46) | KMT2ADPP8DPP9EPHX2OPRD1 | |
| SCHEMBL6111714 | 0.84 | EPHX2 (0.46) | KMT2ADPP8DPP9EPHX2OPRD1 | |
| SCHEMBL12644793 | 0.83 | KMT2A (0.52) | KMT2ADPP8DPP9EPHX2MDM4 | |
| SCHEMBL3489481 | 0.83 | DPP8 (0.42) | KMT2ADPP8DPP9EPHX2OPRD1 | |
| SCHEMBL2414478 | 0.82 | BACE1 (0.41) | KMT2ADPP8DPP9EPHX2OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125805-A1 | SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY | Astex Therapeutics Limited (GB) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075109-A1 | SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY | ASTEX THERAPEUTICS LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |