⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1162349 | 0.81 | TSHR (0.42) | — | |
| SCHEMBL20729465 | 0.71 | — | — | |
| SCHEMBL8195363 | 0.69 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL7463378 | 0.69 | — | — | |
| SCHEMBL11772819 | 0.69 | CA1 (0.36) | — | |
| SCHEMBL71329 | 0.69 | — | — | |
| SCHEMBL7568984 | 0.69 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL83058 | 0.67 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL16758404 | 0.66 | — | — | |
| SCHEMBL15763954 | 0.65 | CA1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111386273-B | Salts of pyrrolotriazine derivatives useful as TAM inhibitors | 因赛特公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-109348715-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-111386273-A | Salts of pyrrolotriazine derivatives useful as TAM inhibitors | 因赛特公司 | 2020-07-07 | — | — | CN | disclosed |
| CN-108047201-A | Uracil derivative as AXL and c-MET kinase inhibitors | 亚尼塔公司 | 2018-05-18 | — | — | CN | disclosed |
| CN-106029661-B | Pyrazolo [1,5-A ] pyridine derivatives and methods of use thereof | 亚尼塔公司 | 2017-11-03 | — | — | CN | disclosed |
| CN-103958497-B | uracil derivatives as AXL and c-MET kinase inhibitors | 亚尼塔公司 | 2017-09-01 | — | — | CN | disclosed |
| CN-102702193-A | Anti-viral compounds | ABBOTT LAB | 2012-10-03 | — | — | CN | disclosed |
| CN-102702194-A | Anti-viral compounds | ABBOTT LAB | 2012-10-03 | — | — | CN | disclosed |
| US-4593028-A | 5-hetero aryl-substituted-2-pyridones useful as cardiotonic agents for treatment of congestive heart failure | WILLIAM H. RORER, INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0118528-A4 | 5-(BICYCLIC NITROGEN-HETEROARYL)PYRID-2-ONES AND THEIR USE FOR INCREASING CARDIAC CONTRACTILITY. | RORER INTERNAT OVERSEAS INC (US) | 1985-09-09 | — | — | EP | disclosed |
| US-4539321-A | 5-Diaza-aryl-3-substituted pyridone compounds | WILLIAM H. RORER, INC. (US) | 1985-09-03 | — | — | US | disclosed |
| EP-0116552-A4 | PYRIDONE COMPOUNDS. | RORER INTERNAT OVERSEAS INC (US) | 1985-04-25 | — | — | EP | disclosed |
| EP-0134165-A2 | 7-(Pyrrol-1-yl)-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 7-(pyrrol-1-yl)-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives, their preparation and use as medicaments | PROVESAN S.A. (CH) | 1985-03-13 | — | — | EP | disclosed |
| EP-0118528-A1 | 5-(BICYCLIC NITROGEN-HETEROARYL)PYRID-2-ONES AND THEIR USE FOR INCREASING CARDIAC CONTRACTILITY | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1984-09-19 | — | — | EP | disclosed |
| EP-0116552-A1 | PYRIDONE COMPOUNDS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1984-08-29 | — | — | EP | disclosed |
| WO-1984000685-A1 | PYRIDONE COMPOUNDS | RORER INT OVERSEAS (US) | 1984-03-01 | — | — | WO | disclosed |
| WO-1984000756-A1 | 5 (BICYCLIC NITROGEN-HETEROARYL)PYRID-2-ONES AND THEIR USE FOR INCREASING CARDIAC CONTRACTILLITY | RORER INT OVERSEAS (US) | 1984-03-01 | — | — | WO | disclosed |
| US-4432979-A | Pyridone compounds | WILLIAM H. RORER, INC. (US) | 1984-02-21 | — | — | US | disclosed |