Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 1.00 |
| ▸ | EGFR | P00533 | 4/20 | 1.00 |
| ▸ | ITK | Q08881 | 3/20 | 1.00 |
| ▸ | LCK | P06239 | 2/20 | 1.00 |
| ▸ | TEC | P42680 | 3/20 | 0.75 |
| ▸ | BMX | P51813 | 3/20 | 0.75 |
| ▸ | TXK | P42681 | 2/20 | 0.75 |
| ▸ | LYN | P07948 | 2/20 | 0.75 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.75 |
| ▸ | FLT3 | P36888 | 2/20 | 0.75 |
| ▸ | BLK | P51451 | 2/20 | 0.75 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.75 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.75 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.75 |
| ▸ | LATS1 | O95835 | 1/20 | 0.75 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.75 |
| ▸ | ABL1 | P00519 | 1/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.75 |
| ▸ | FYN | P06241 | 1/20 | 0.75 |
| ▸ | PGR | P06401 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410333 | 1.00 | BTK (1.00) | BTKEGFRITKLCKTEC | |
| SCHEMBL29663941 | 1.00 | BTK (1.00) | BTKEGFRITKLCKTEC | |
| SCHEMBL18211764 | 0.95 | BTK (0.91) | BTKEGFRITKLCKTEC | |
| SCHEMBL18211765 | 0.95 | BTK (0.91) | BTKEGFRITKLCKTEC | |
| SCHEMBL18211763 | 0.95 | BTK (0.91) | BTKEGFRITKLCKTEC | |
| SCHEMBL21330635 | 0.92 | BTK (0.91) | BTKEGFRITKLCKFLT3 | |
| SCHEMBL21330631 | 0.92 | BTK (0.91) | BTKEGFRITKLCKFLT3 | |
| SCHEMBL202258 | 0.90 | BTK (1.00) | BTKEGFRITKLCKTEC | |
| SCHEMBL15851229 | 0.90 | BTK (1.00) | BTKEGFRITKLCKTEC | |
| SCHEMBL23226152 | 0.89 | BTK (0.83) | BTKEGFRITKLCKTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152115-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC | 2015-06-04 | — | — | US | claimed |
| US-20130018060-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2013-01-17 | — | — | US | claimed |
| US-20120277225-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2012-11-01 | — | — | US | claimed |
| US-20120277255-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2012-11-01 | — | — | US | claimed |
| US-20120065201-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2012-03-15 | — | — | US | claimed |
| US-20240317756-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2024-09-26 | — | — | US | disclosed |
| US-20240000782-A1 | METHODS AND COMPOSITIONS FOR TREATING AN OPHTHALMIC CONDITION | TELIOS PHARMA, INC. (US) | 2024-01-04 | — | — | US | disclosed |
| US-20220213106-A1 | Inhibitors of Bruton's Tyrosine Kinase | PHARMACYCLICS LLC (US) | 2022-07-07 | — | — | US | disclosed |
| US-20200289515-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | PHARMACYCLICS, INC. | 2020-09-17 | — | — | US | disclosed |
| US-20200276199-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | PHARMACYCLICS LLC | 2020-09-03 | — | — | US | disclosed |
| US-10596183-B2 | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2020-03-24 | — | — | US | disclosed |
| US-20200055859-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2020-02-20 | — | — | US | disclosed |
| US-20110224235-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | PHARMACYCLICS, INC. (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2307025-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | Pharmacyclics, Inc. (US) | 2011-04-13 | — | — | EP | disclosed |
| US-20100254905-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC | 2010-10-07 | — | — | US | disclosed |
| US-20100254905-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC | 2010-10-07 | — | — | US | disclosed |
| US-20100254905-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC | 2010-10-07 | — | — | US | disclosed |
| WO-2010009342-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | PHARMACYCLICS, INC. (US) | 2010-01-21 | — | — | WO | disclosed |
| EP-2139487-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | Pharmacyclics, Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008121742-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277255-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885ITK 467/4885 |
| US-20220213106-A1 | Inhibitors of Bruton's Tyrosine Kinase | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885ITK 467/4885 |
| US-10596183-B2 | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases | BTK, BCL9, BCL9L | BTK 1/4885EGFR 538/4885ITK 305/4885 |
| US-20240000782-A1 | METHODS AND COMPOSITIONS FOR TREATING AN OPHTHALMIC CONDITION | BTK, SYK, LCK | BTK 1/4885EGFR 812/4885ITK 218/4885 |
| US-20200289515-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | BTK, ABL1, LYN | BTK 1/4885EGFR 497/4885ITK 124/4885 |
| US-20240317756-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885ITK 467/4885 |
| US-20120277225-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885ITK 467/4885 |
| US-20100254905-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885ITK 467/4885 |
| US-20150152115-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885ITK 467/4885 |
| US-20130018060-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885ITK 467/4885 |
| US-20200055859-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 456/4885ITK 319/4885 |
| US-20200276199-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | BTK, ABL1, LYN | BTK 1/4885EGFR 497/4885ITK 124/4885 |
| US-20110224235-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | BTK, ABL1, LYN | BTK 1/4885EGFR 497/4885ITK 124/4885 |
| US-20120065201-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885ITK 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.