Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 6/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561535 | 0.92 | MAP4K1 (0.39) | MAP4K1PTPN11ATMABL1IGF1R | |
| SCHEMBL13342628 | 0.83 | MAP4K1 (0.42) | MAP4K1PTPN11ABL1MAPTTSHR | |
| SCHEMBL3564795 | 0.83 | MAP4K1 (0.44) | MAP4K1PTPN11ABL1MAPTTSHR | |
| SCHEMBL3565148 | 0.82 | MAP4K1 (0.59) | MAP4K1PTPN11ABL1MAPTTSHR | |
| SCHEMBL3568123 | 0.82 | PTPN11 (0.48) | MAP4K1PTPN11MAPTTSHRSMN1; SMN2 | |
| SCHEMBL3565147 | 0.82 | MAP4K1 (0.48) | MAP4K1PTPN11ABL1MAPTTSHR | |
| SCHEMBL13342660 | 0.81 | MAP4K1 (0.39) | MAP4K1PTPN11MAPTKDM4ETSHR | |
| SCHEMBL14208401 | 0.80 | PTPN11 (0.42) | MAP4K1PTPN11ABL1MAPTTSHR | |
| SCHEMBL3568986 | 0.79 | MAP4K1 (0.44) | MAP4K1PTPN11ABL1PIK3CAMAPT | |
| SCHEMBL3563287 | 0.79 | PTPN11 (0.43) | MAP4K1PTPN11ABL1PIK3CAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134343-A2 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008124849-A2 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |