Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 20/20 | 0.72 |
| ▸ | PIK3CB | P42338 | 20/20 | 0.72 |
| ▸ | PIK3CG | P48736 | 20/20 | 0.72 |
| ▸ | MTOR | P42345 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445830 | 0.92 | PIK3CA (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL4437806 | 0.91 | PIK3CD (0.72) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL4437975 | 0.89 | PIK3CA (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL4448427 | 0.89 | PIK3CA (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL12464542 | 0.89 | PIK3CD (0.75) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL4447453 | 0.88 | PIK3CA (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL13557953 | 0.86 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL1181612 | 0.86 | PIK3CA (0.79) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL4440499 | 0.85 | PIK3CA (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL1181393 | 0.85 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114949-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2009-11-11 | — | — | EP | claimed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | claimed |
| EP-2114949-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |