SCHEMBL4440305

SCHEMBL4440305

OC1C=CCc2ccccc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
ACP3 P15309 1/20 0.34
HDAC4 P56524 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC5 Q9UQL6 1/20 0.32
RET P07949 1/20 0.32
HTR2C P28335 1/20 0.32
HRH1 P35367 1/20 0.32
MAPT P10636 2/20 0.32
ALDH1A1 P00352 2/20 0.32
KDM4E B2RXH2 1/20 0.32
HPGD P15428 1/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32
HBB P68871 1/20 0.32
GAA P10253 1/20 0.32
GRIN2D O15399 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31276808 1.00 HTR2A (0.35) HTR2AMAOAMAOBACP3HDAC4
SCHEMBL3078945 0.77 HTR2A (0.38) HTR2AMAOAMAOBACP3HDAC4
SCHEMBL6763552 0.77 HTR2A (0.38) HTR2AMAOAMAOBACP3HDAC4
SCHEMBL528662 0.77 HTR2A (0.38) HTR2AMAOAMAOBACP3HDAC4
SCHEMBL5405494 0.76 MEN1 (0.38) MAPTALDH1A1KDM4E
SCHEMBL8849849 0.74 HTR2A (0.36) HTR2AHTR2CHRH1MAPTALDH1A1
SCHEMBL4925778 0.74 HTR2A (0.45) HTR2ARETHTR2CHRH1ANPEP
SCHEMBL22328101 0.74 HTR2A (0.35) HTR2ARETHTR2CHRH1GRIN2D
SCHEMBL2525691 0.74 HTR2A (0.35) HTR2AMAOAMAOBACP3HDAC4
SCHEMBL3705916 0.74 HTR2A (0.35) HTR2ARETHTR2CHRH1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2125753-A1 FUSED HETEROCYCLIC COMPOUNDS HAVING CRF ANTAGONISTIC ACTIVITY Takeda Pharmaceutical Company Limited (JP) 2009-12-02 EP disclosed
WO-2008082003-A1 FUSED HETEROCYCLIC COMPOUNDS HAVING CRF ANTAGONISTIC ACTIVITY TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-07-10 WO disclosed
EP-1056737-B1 PROCESS FOR THE PREPARATION OF SIMVASTATIN AND DERIVATIVES THEREOF KRKA TOVARNA ZDRAVIL D D (SI) 2003-06-18 EP disclosed
US-6252091-B1 PROTECTING A DIOL LACTONE; ACYLATION; IN PRESENCE OF N-METHYLIMIDAZOLE KRKA, TOVARNA ZDRAVIL, D.D. (SI) 2001-06-26 US disclosed
EP-1100769-A1 AMINOMETHYLCARBOXYLIC ACID DERIVATIVES Akzo Nobel N.V. (NL) 2001-05-23 EP disclosed
WO-2000007978-A1 AMINOMETHYLCARBOXYLIC ACID DERIVATIVES AKZO NOBEL N.V. (NL) 2000-02-17 WO disclosed
US-4996245-A Aromatic polycarbonates stabilized by adding 2-mercapto-benzothiazole and 2,5-dimercapto-1,3,4-thiadiazole GENERAL ELECTRIC COMPANY (US) 1991-02-26 US disclosed
US-4996246-A 2,4-Pentanedione GENERAL ELECTRIC COMPANY (US) 1991-02-26 US disclosed
US-4996248-A Pyran compounds GENERAL ELECTIC COMPANY (US) 1991-02-26 US disclosed
EP-0107805-B1 MIXED 2,2,6,6-TETRAMETHYL PIPERIDINYL CARBOXYLIC ACID ESTER AND AMIDE LIGHT STABILIZERS AND STABILIZED SYNTHETIC POLYMERS ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1989-12-13 EP disclosed
US-4876309-A 3,4-DIHYDRO-2-ETHOXY-2H-PYRAN STABILIZER FOR POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 1989-10-24 US disclosed
EP-0149259-B1 ALKYLIDENE BISPHENOL PHOSPHITES AND PHOSPHATES HAVING 2,2,6,6-TETRAMETHYL PIPERIDINYL GROUPS AND SYNTHETIC RESIN COMPOSITIONS ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1989-06-14 EP disclosed
EP-0108993-B1 OLIGOMERS OF 2,2,6,6-TETRAMETHYLPIPERIDINOL, POLYCARBOXYLIC ACID ESTERS AND SYNTHETIC POLYMER COMPOSITIONS ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1986-12-17 EP disclosed
EP-0058434-B1 N-2-HYDROXYPROPYL PIPERIDINES AND PROCESS FOR PREPARING THE SAME ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1985-06-19 EP disclosed