Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4439326 | 0.85 | PIK3CA (0.53) | PIK3CAPIK3CBMTORALDH1A1HSD17B10 | |
| SCHEMBL5138967 | 0.85 | PIK3CA (0.50) | PIK3CAPIK3CBMTORSMN1; SMN2PRKDC | |
| SCHEMBL1181057 | 0.81 | PIK3CA (0.53) | PIK3CAPIK3CBMTORPOLB | |
| SCHEMBL5139891 | 0.80 | HSD17B10 (0.49) | PIK3CAPIK3CBMTORSMN1; SMN2P2RY12 | |
| SCHEMBL4566631 | 0.78 | PIK3CA (0.47) | PIK3CAPIK3CBKDM4EALDH1A1POLB | |
| SCHEMBL5101883 | 0.77 | PIK3CA (0.46) | PIK3CAPIK3CBMTORSMN1; SMN2PRKDC | |
| SCHEMBL1862478 | 0.77 | PIK3CA (0.67) | PIK3CAPIK3CBMTORSMN1; SMN2KDM4E | |
| SCHEMBL5139108 | 0.76 | PIK3CA (0.47) | PIK3CAPIK3CBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1180779 | 0.76 | PIK3CA (0.44) | PIK3CAPIK3CBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL190250 | 0.75 | PIK3CA (0.50) | PIK3CAPIK3CBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114949-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |