Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL444082 | 1.00 | SLC18A3 (0.41) | SLC18A3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12296040 | 0.87 | SLC18A3 (0.40) | SLC18A3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4602773 | 0.84 | SLC18A3 (0.40) | SLC18A3 | |
| SCHEMBL4602108 | 0.84 | SLC18A3 (0.40) | SLC18A3 | |
| SCHEMBL439951 | 0.81 | SLC6A4 (0.46) | KCNA5ALDH1A1 | |
| SCHEMBL439953 | 0.81 | SLC6A4 (0.46) | KCNA5ALDH1A1 | |
| SCHEMBL439952 | 0.81 | SLC6A4 (0.46) | KCNA5ALDH1A1 | |
| SCHEMBL438872 | 0.81 | SLC6A4 (0.46) | KCNA5ALDH1A1 | |
| SCHEMBL3038532 | 0.80 | ELANE (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16481562 | 0.77 | SLC6A4 (0.39) | KCNA5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8618311-B2 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2013-12-31 | — | — | US | disclosed |
| EP-1915340-B1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP (CA) | 2013-08-07 | — | — | EP | disclosed |
| US-20130090483-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2013-04-11 | — | — | US | disclosed |
| US-8344162-B2 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2013-01-01 | — | — | US | disclosed |
| US-20120271057-A9 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2012-10-25 | — | — | US | disclosed |
| US-20120065408-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2012-03-15 | — | — | US | disclosed |
| US-8080673-B2 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2011-12-20 | — | — | US | disclosed |
| US-20100217014-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2010-08-26 | — | — | US | disclosed |
| US-7754897-B2 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2010-07-13 | — | — | US | disclosed |
| EP-1915340-A2 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | Cardiome Pharma Corp. (CA) | 2008-04-30 | — | — | EP | disclosed |
| US-20070015924-A1 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2007-01-18 | — | — | US | disclosed |
| WO-2006138673-A2 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065408-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CYP2D6, CYP3A43, CYP2F1 | SLC18A3 2069/4885PSEN1 4025/4885PSEN2 3838/4885 |
| US-20070015924-A1 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CYP2D6, CYP3A43, CYP2F1 | SLC18A3 2069/4885PSEN1 4025/4885PSEN2 3838/4885 |
| US-20130090483-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CYP2D6, CYP3A43, CYP2F1 | SLC18A3 2069/4885PSEN1 4025/4885PSEN2 3838/4885 |
| US-20100217014-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CYP2D6, CYP3A43, CYP2F1 | SLC18A3 2069/4885PSEN1 4025/4885PSEN2 3838/4885 |
| US-20120271057-A9 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CYP2D6, CYP3A43, CYP2F1 | SLC18A3 2069/4885PSEN1 4025/4885PSEN2 3838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.