Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pazufloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A known ✓ | P11388 | 6/20 | 0.58 |
| ▸ | TOP2B known ✓ | Q02880 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.91 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.91 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | ALB | P02768 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TUBB | P07437 | 1/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pazufloxacin SCHEMBL29380457 | 1.00 | KDM4E (0.91) | KDM4EKMT2AAADATTOP2ATOP2B | |
| Pazufloxacin SCHEMBL8386358 | 0.95 | KDM4E (1.00) | KDM4EKMT2AAADATTOP2ATOP2B | |
| Pazufloxacin SCHEMBL29381001 | 0.95 | KDM4E (1.00) | KDM4EKMT2AAADATTOP2ATOP2B | |
| Pazufloxacin SCHEMBL21074686 | 0.95 | KDM4E (1.00) | KDM4EKMT2AAADATTOP2ATOP2B | |
| Pazufloxacin SCHEMBL34460 | 0.95 | KDM4E (1.00) | KDM4EKMT2AAADATTOP2ATOP2B | |
| Pazufloxacin SCHEMBL9873706 | 0.94 | KDM4E (0.98) | KDM4EKMT2AAADATTOP2ATOP2B | |
| Pazufloxacin SCHEMBL28064894 | 0.94 | KDM4E (0.98) | KDM4EKMT2AAADATTOP2ATOP2B | |
| Pazufloxacin SCHEMBL28659469 | 0.94 | KDM4E (0.98) | KDM4EKMT2AAADATTOP2ATOP2B | |
| Pazufloxacin SCHEMBL9872951 | 0.94 | KDM4E (0.98) | KDM4EKMT2AAADATTOP2ATOP2B | |
| Pazufloxacin SCHEMBL28087423 | 0.94 | KDM4E (0.98) | KDM4EKMT2AAADATTOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119985774-A | Method for detecting photodegradation impurity in pazufloxacin mesylate sodium chloride injection | 安徽恒星制药有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119564700-A | Application of pazufloxacin mesylate in preparation of medicine for treating acute myocardial infarction | 福建中医药大学 | 2025-03-07 | — | — | CN | claimed |
| CN-114354794-B | Quality control method of pazufloxacin mesylate injection | 四川美大康佳乐药业有限公司 | 2025-01-14 | — | — | CN | claimed |
| CN-114965764-B | Diagnosis and treatment of constipation | 陕西安宁云生生物技术有限公司 | 2024-12-31 | — | — | CN | claimed |
| CN-119198971-A | Fingerprint spectrum of chemical indicator for identifying effluent pollution of sewage treatment plant and textile printing and dyeing mill and application thereof | 北京师范大学珠海校区 | 2024-12-27 | — | — | CN | claimed |
| CN-116082717-B | Hydrogel, vascular fiber skeleton, preparation method and application thereof | 领博生物科技(杭州)有限公司 | 2024-06-18 | — | — | CN | claimed |
| CN-116270448-B | Preparation method of pazufloxacin mesylate liquid preparation | 浙江莎普爱思药业股份有限公司 | 2024-01-30 | — | — | CN | claimed |
| WO-2023222083-A1 | CONSTIPATION DIAGNOSIS AND TREATMENT | 陕西安宁云生生物技术有限公司 | 2023-11-23 | — | — | WO | claimed |
| CN-115919761-B | Pazufloxacin mesylate liquid preparation and preparation method thereof | 浙江莎普爱思药业股份有限公司 | 2023-07-21 | — | — | CN | claimed |
| CN-112663057-B | Preparation method of micro-arc titanium oxide surface hydroxyapatite/carrier hydrogel composite coating | 西安交通大学 | 2023-06-27 | — | — | CN | claimed |
| CN-113144197-A | Method of treating topical microbial infections | 罗达制药公司 | 2021-07-23 | — | — | CN | claimed |
| CN-112663057-A | Preparation method of micro-arc titanium oxide surface hydroxyapatite/drug-loaded hydrogel composite coating | 西安交通大学 | 2021-04-16 | — | — | CN | claimed |
| CN-211751067-U | Ampoule bottle for storing pazufloxacin mesylate injection preparation | 北京四环科宝制药有限公司 | 2020-10-27 | — | — | CN | claimed |
| CN-111771895-A | New application of quinolone compounds in preventing and treating plant bacterial diseases and citrus canker | 兰州大学 | 2020-10-16 | — | — | CN | claimed |
| CN-110801435-A | Pazufloxacin mesylate for injection and preparation method thereof | 南京臣功制药股份有限公司 | 2020-02-18 | — | — | CN | claimed |
| CN-105287371-B | A kind of pazufloxacin mesylate injection composition and preparation method thereof | 河北智同生物制药股份有限公司 | 2019-09-13 | — | — | CN | claimed |
| CN-105287371-A | Pazufloxacin mesilate injection composition and preparation method thereof | HEBEI ZHITONG BIOLOG PHARMACEUTICAL CO LTD | 2016-02-03 | — | — | CN | claimed |
| CN-103487520-B | Chiral stationary-phase detection method for dextroisomer of pazufloxacin mesilate injection | CHENGDU BAIYU SCIENCE & TECHNOLOGY PHARMACEUTICAL CO LTD | 2015-04-29 | — | — | CN | claimed |
| CN-103487520-A | Chiral stationary-phase detection method for dextroisomer of pazufloxacin mesilate injection | CHENGDU BAIYU SCIENCE & TECHNOLOGY PHARMACEUTICAL CO LTD | 2014-01-01 | — | — | CN | claimed |
| CN-103487521-A | Detection method for dextroisomer of pazufloxacin mesilate injection | CHENGDU BAIYU SCIENCE & TECHNOLOGY PHARMACEUTICAL CO LTD | 2014-01-01 | — | — | CN | claimed |