Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 9/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4605637 | 1.00 | NPC1 (0.40) | NPC1RXFP1PTPN1PTPN6PTPN11 | |
| SCHEMBL4442040 | 0.76 | NPC1 (0.40) | NPC1RXFP1PTPN1PTPN6PTPN11 | |
| SCHEMBL4449737 | 0.76 | NPC1 (0.40) | NPC1RXFP1PTPN1PTPN6PTPN11 | |
| Hydrochloric Acid SCHEMBL3605048 | 0.75 | NPC1 (0.45) | NPC1RXFP1PTPN1PTPN6PTPN11 | |
| SCHEMBL3610730 | 0.70 | NPC1 (0.39) | NPC1RXFP1PTPN1PTPN6PTPN11 | |
| SCHEMBL3646654 | 0.69 | KDM1A (0.51) | NPC1RXFP1PTPN1PTPN6PTPN11 | |
| SCHEMBL3646653 | 0.69 | KDM1A (0.51) | NPC1RXFP1PTPN1PTPN6PTPN11 | |
| SCHEMBL3600203 | 0.67 | KDM1A (0.49) | NPC1RXFP1PTPN1PTPN6PTPN11 | |
| SCHEMBL3605976 | 0.67 | KDM1A (0.49) | NPC1RXFP1PTPN1PTPN6PTPN11 | |
| SCHEMBL3600206 | 0.67 | KDM1A (0.49) | NPC1RXFP1PTPN1PTPN6PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121612-A1 | HETEROARYLCYCLOPROPANECARBOXAMIDES AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008080511-A1 | HETEROARYLCYCLOPROPANECARBOXAMIDES AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2008-07-10 | — | — | WO | disclosed |