Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44429 | 1.00 | KDR (0.46) | KDRCYP1A2CYP1A1CYP1B1RPS6KA3 | |
| SCHEMBL6031030 | 0.90 | RPS6KA3 (0.50) | KDRCYP1A2CYP1A1CYP1B1RPS6KA3 | |
| SCHEMBL3898497 | 0.90 | RPS6KA3 (0.50) | KDRCYP1A2CYP1A1CYP1B1RPS6KA3 | |
| SCHEMBL3930279 | 0.85 | CYP1A2 (0.43) | CYP1A2CYP1A1CYP1B1MAOBBACE1 | |
| SCHEMBL3930273 | 0.85 | CYP1A2 (0.43) | CYP1A2CYP1A1CYP1B1MAOBBACE1 | |
| SCHEMBL8148781 | 0.84 | BACE1 (0.51) | KDRBACE1HTTHDAC3HDAC1 | |
| SCHEMBL8148789 | 0.84 | BACE1 (0.51) | KDRBACE1HTTHDAC3HDAC1 | |
| SCHEMBL20568577 | 0.83 | KDR (0.43) | KDRCYP1A2CYP1A1CYP1B1RPS6KA3 | |
| SCHEMBL6821841 | 0.83 | CYP1A2 (0.42) | CYP1A2CYP1A1CYP1B1MAOBBACE1 | |
| Hydrochloric Acid SCHEMBL6821843 | 0.83 | CYP1A2 (0.42) | CYP1A2CYP1A1CYP1B1MAOBBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110313196-A1 | NOVEL PROCESS | HOFFMANN-LA ROCHE, INC. | 2011-12-22 | — | — | US | disclosed |
| WO-2011157670-A2 | NOVEL PROCESS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110313196-A1 | NOVEL PROCESS | CYP3A5, CYP3A4, GBA1 | KDR 3772/4885CYP1A2 119/4885CYP1A1 532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.