Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 11/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 11/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 9/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4451903 | 0.89 | ITGB1 (0.36) | ITGB1ITGA4ITGB7ITGAVALDH1A1 | |
| SCHEMBL4564578 | 0.88 | ITGB1 (0.40) | ITGB1ITGA4ITGB7MAPTSMN1; SMN2 | |
| SCHEMBL4453860 | 0.84 | ITGB1 (0.38) | ITGB1ITGA4ITGB7LMNASMN1; SMN2 | |
| SCHEMBL4448892 | 0.83 | ITGB1 (0.38) | ITGB1ITGA4ITGB7LMNAITGAV | |
| SCHEMBL2814333 | 0.83 | ITGB1 (0.35) | ITGB1ITGA4ITGB7MAPTLMNA | |
| SCHEMBL4458135 | 0.82 | ITGB1 (0.38) | ITGB1ITGA4ITGB7ITGAV | |
| SCHEMBL4457975 | 0.81 | ITGB1 (0.39) | ITGB1ITGA4ITGB7ITGAV | |
| SCHEMBL4453759 | 0.81 | ITGB1 (0.41) | ITGB1ITGA4ITGB7ITGAVALDH1A1 | |
| SCHEMBL4566570 | 0.80 | ITGB1 (0.44) | ITGB1ITGA4ITGB7ITGAVALDH1A1 | |
| SCHEMBL4458281 | 0.79 | ITGB1 (0.53) | ITGB1ITGA4ITGB7ITGAVALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635822-A4 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | ELAN PHARM INC (US) | 2009-06-24 | — | — | EP | disclosed |
| EP-1635822-A2 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | Elan Pharmaceuticals, Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005000246-A2 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | ELAN PHARMACEUTICALS, INC. (US) | 2005-01-06 | — | — | WO | disclosed |