Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.72 |
| ▸ | LCK | P06239 | 5/20 | 0.68 |
| ▸ | KDR | P35968 | 5/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.68 |
| ▸ | JAK3 | P52333 | 3/20 | 0.68 |
| ▸ | TEK | Q02763 | 2/20 | 0.68 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.65 |
| ▸ | RAF1 | P04049 | 5/20 | 0.63 |
| ▸ | BRAF | P15056 | 5/20 | 0.62 |
| ▸ | BTK | Q06187 | 2/20 | 0.62 |
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.61 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435452 | 0.91 | MAPK14 (0.68) | PTGS1LCKKDRMAPK14JAK3 | |
| SCHEMBL4990970 | 0.90 | PTGS1 (0.69) | PTGS1LCKKDRMAPK14JAK3 | |
| SCHEMBL13220190 | 0.86 | LCK (0.76) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5000446 | 0.85 | RAF1 (0.61) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL3454009 | 0.84 | PTGS1 (1.00) | PTGS1LCKBTKMEN1HTT | |
| SCHEMBL374471 | 0.83 | PTGS1 (0.70) | PTGS1LCKKDRMAPK14DDR2 | |
| SCHEMBL16037428 | 0.83 | BRAF (0.67) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL13198172 | 0.83 | BRAF (0.74) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL13198189 | 0.83 | KDR (0.77) | LCKKDRMAPK14JAK3TEK | |
| Hydrochloric Acid SCHEMBL5004557 | 0.82 | PTGS1 (0.68) | PTGS1LCKKDRMAPK14DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841318-B2 | Substituted heterocycles as janus kinase inhibitors | INCYTE CORPORATION (US) | 2014-09-23 | — | — | US | disclosed |
| US-20130274257-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION | 2013-10-17 | — | — | US | disclosed |
| US-8513270-B2 | Substituted heterocycles as Janus kinase inhibitors | INCYTE CORPORATION (US) | 2013-08-20 | — | — | US | disclosed |
| EP-2121692-B1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | INCYTE CORP (US) | 2013-04-10 | — | — | EP | disclosed |
| EP-2121692-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20080188500-A1 | e.g. N-[4-methyl-3-(9H-pyrimido[4,5-b]indol-7-yl)phenyl]-3-(trifluoromethyl)benzamide; Janus kinases inhibitor; anticarcinogenic agent; immune-related diseases, skin disorders, myeloid proliferative disorders | INCYTE CORPORATION | 2008-08-07 | — | — | US | disclosed |
| WO-2008079965-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188500-A1 | e.g. N-[4-methyl-3-(9H-pyrimido[4,5-b]indol-7-yl)phenyl]-3-(trifluoromethyl)benzamide; Janus kinases inhibitor; anticarcinogenic agent; immune-related diseases, skin disorders, myeloid proliferative disorders | JAK3, JAK1, JAK2 | PTGS1 816/4885LCK 50/4885KDR 1661/4885 |
| US-20130274257-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | JAK1, JAK3, JAK2 | PTGS1 1475/4885LCK 34/4885KDR 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.