Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 19/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 18/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 18/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12495335 | 0.85 | PIM1 (0.36) | PIM1PIM3PIM2 | |
| SCHEMBL4437200 | 0.83 | PIM1 (0.38) | PIM1PIM3PIM2 | |
| SCHEMBL4439362 | 0.82 | PIM2 (0.34) | PIM1PIM3PIM2 | |
| SCHEMBL3239889 | 0.77 | KDM4E (0.33) | — | |
| SCHEMBL3239906 | 0.77 | KDM4E (0.33) | — | |
| SCHEMBL4438027 | 0.76 | PIM1 (0.40) | PIM1PIM3PIM2 | |
| SCHEMBL15103573 | 0.75 | PIM1 (0.39) | PIM1PIM3PIM2 | |
| SCHEMBL3241523 | 0.74 | SSTR4 (0.30) | — | |
| SCHEMBL11908632 | 0.74 | PIM1 (0.46) | PIM1PIM3PIM2 | |
| SCHEMBL17440459 | 0.73 | PIM1 (0.43) | PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |