Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.52 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442994 | 0.89 | CCR8 (0.49) | CYP19A1CCR8PKMLMNANSD2 | |
| SCHEMBL4443216 | 0.84 | CCR8 (0.52) | CYP19A1CCR8NSD2FABP4EDNRA | |
| SCHEMBL4453211 | 0.83 | NSD2 (0.52) | CYP19A1CCR8NSD2FABP4SMN1; SMN2 | |
| SCHEMBL4445014 | 0.83 | NSD2 (0.51) | CYP19A1CCR8NSD2FABP4EDNRA | |
| SCHEMBL4448429 | 0.83 | MCL1 (0.57) | CCR8LMNANSD2FABP4EDNRA | |
| SCHEMBL4452471 | 0.83 | CCR8 (0.51) | CCR8NSD2FABP4EDNRAALDH1A1 | |
| SCHEMBL4494199 | 0.82 | CYP19A1 (0.58) | CYP1A2CYP3A4CYP2C19CYP19A1MEN1 | |
| SCHEMBL4454907 | 0.81 | CCR8 (0.51) | CYP19A1CCR8NSD2FABP4EDNRA | |
| SCHEMBL4443345 | 0.81 | CCR8 (0.48) | CCR8LMNANSD2FABP4SMN1; SMN2 | |
| SCHEMBL4445436 | 0.80 | NSD2 (0.67) | CYP1A2CYP3A4CYP2C19CYP19A1NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547716-B2 | Sulfonamide derivatives | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2009-06-16 | — | — | US | disclosed |
| EP-1402890-B1 | SULFONAMIDE DERIVATIVES | INST MED MOLECULAR DESIGN INC (JP) | 2008-01-09 | — | — | EP | disclosed |
| US-20040234622-A1 | Sulfonamide derivatives | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2004-11-25 | — | — | US | disclosed |
| EP-1402890-A1 | SULFONAMIDE DERIVATIVES | Institute of Medicinal Molecular Design, Inc. (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040234622-A1 | Sulfonamide derivatives | PCNA, TOP2A, DDB1 | CYP1A2 1951/4885CYP3A4 2664/4885CYP2C19 3235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.