Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.56 |
| ▸ | MTOR | P42345 | 11/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.56 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437644 | 0.88 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL4446859 | 0.88 | PIK3CA (0.54) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL5102260 | 0.86 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL4446857 | 0.86 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL4435267 | 0.85 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL4444175 | 0.84 | PIK3CA (0.62) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL4440950 | 0.84 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL4439039 | 0.83 | PIK3CA (0.68) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL4435360 | 0.83 | PIK3CA (0.66) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL4436259 | 0.83 | PIK3CA (0.60) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | claimed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | claimed |
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | disclosed |