Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 11/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434114 | 0.87 | MTOR (0.67) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4447550 | 0.87 | MTOR (0.67) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL5109764 | 0.87 | MTOR (0.67) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4446923 | 0.87 | MTOR (0.86) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4443689 | 0.87 | MTOR (0.74) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4439954 | 0.85 | MTOR (0.72) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4445535 | 0.85 | MTOR (0.71) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4433930 | 0.84 | MTOR (0.60) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4446954 | 0.82 | MTOR (0.59) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL27943062 | 0.82 | MTOR (0.59) | MTORPIK3CAPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | disclosed |