Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 14/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.61 |
| ▸ | SYK | P43405 | 1/20 | 0.61 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.61 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438742 | 0.95 | MTOR (0.66) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4437404 | 0.92 | MTOR (0.58) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4438960 | 0.90 | MTOR (0.71) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4438418 | 0.87 | MTOR (0.57) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4439836 | 0.87 | MTOR (0.77) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4447622 | 0.86 | MTOR (0.76) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4437569 | 0.86 | PIK3CA (0.64) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4440511 | 0.85 | PIK3CA (0.67) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4437642 | 0.85 | MTOR (0.60) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4437397 | 0.85 | MTOR (0.68) | MTORPIK3CAPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | claimed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | claimed |
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | disclosed |