Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | PHGDH | O43175 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1265183 | 0.86 | MAPT (0.68) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3485710 | 0.85 | MAPT (0.73) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1110533 | 0.83 | MAPT (0.71) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1110574 | 0.83 | MAPT (0.71) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1110528 | 0.83 | MAPT (0.71) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1110483 | 0.83 | MAPT (0.71) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL28322333 | 0.82 | MAPT (0.69) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL28322332 | 0.82 | MAPT (0.65) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL23850176 | 0.81 | MAPT (0.81) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL615409 | 0.81 | MAPT (0.68) | MAPTMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |