Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.48 |
| ▸ | CCND1 | P24385 | 10/20 | 0.48 |
| ▸ | CCND3 | P30281 | 5/20 | 0.48 |
| ▸ | CCND2 | P30279 | 4/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL4343310 | 0.86 | CDK4 (0.38) | CDK4CCND1CCND3CCND2CDK6 | |
| SCHEMBL4065385 | 0.84 | CDK4 (0.48) | CDK4CCND1CCND3CCND2CDK6 | |
| SCHEMBL4067659 | 0.71 | CDK2 (0.39) | CDK4CCND1CCND3CCND2CDK6 | |
| SCHEMBL13812507 | 0.70 | CTSC (0.45) | CDK4CCND1CCND3CDK6CDK1 | |
| SCHEMBL4073403 | 0.70 | CDK4 (0.54) | CDK4CCND1CCND3CCND2CDK6 | |
| SCHEMBL1919279 | 0.70 | STK17A (0.49) | CDK4CCND1CCND3CCND2CDK1 | |
| SCHEMBL4065163 | 0.69 | CDK4 (0.58) | CDK4CCND1CCND3CCND2CDK6 | |
| Ammonia Solution, Strong SCHEMBL4442788 | 0.69 | CDK4 (0.39) | CDK4CCND1CCND3CCND2CDK6 | |
| Ammonia Solution, Strong SCHEMBL4336001 | 0.69 | CDK4 (0.39) | CDK4CCND1CCND3CCND2CDK6 | |
| SCHEMBL4833020 | 0.69 | CDK4 (0.78) | CDK4CCND1CCND3CCND2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040236084-A1 | E.g., 4-Cyclopentylamino-2-(5-piperazin-1-yl-pyridin-2-ylamino)-pyrimidine-5-carbonitrile; potent inhibitors of cyclin-dependent kinases useful in treating cell proliferative disorders | PFIZER INC | 2004-11-25 | — | — | US | claimed |
| US-20090030005-A1 | Combinations for the treatment of cancer | AMGEN INC. (US) | 2009-01-29 | — | — | US | disclosed |
| US-20050222163-A1 | Combinations of signal transduction inhibitors | PFIZER INC | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236084-A1 | E.g., 4-Cyclopentylamino-2-(5-piperazin-1-yl-pyridin-2-ylamino)-pyrimidine-5-carbonitrile; potent inhibitors of cyclin-dependent kinases useful in treating cell proliferative disorders | CDK4, CCNA1, CCNI | CDK4 1/4885CCND1 11/4885CCND3 32/4885 |
| US-20050222163-A1 | Combinations of signal transduction inhibitors | CDK4, CDK3, CDK2 | CDK4 1/4885CCND1 66/4885CCND3 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.