Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.63 |
| ▸ | APP | P05067 | 6/20 | 0.63 |
| ▸ | SNCA | P37840 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.58 |
| ▸ | NPC1 | O15118 | 10/20 | 0.58 |
| ▸ | RAB9A | P51151 | 10/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | GLA | P06280 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 7/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042570 | 0.85 | MAPT (0.57) | MAPTAPPSNCAKDM4ENPC1 | |
| SCHEMBL24706375 | 0.83 | APP (0.62) | MAPTAPPSNCAKDM4ENPC1 | |
| SCHEMBL24706377 | 0.83 | SMN1; SMN2 (0.51) | MAPTAPPSNCAKDM4ENPC1 | |
| SCHEMBL24706360 | 0.83 | APP (0.61) | MAPTAPPSNCATP53GAA | |
| SCHEMBL9868410 | 0.82 | MAPT (0.62) | MAPTAPPSNCAKDM4ENPC1 | |
| SCHEMBL24706024 | 0.82 | APP (0.48) | MAPTAPPSNCAKDM4ENPC1 | |
| SCHEMBL24707368 | 0.82 | APP (0.44) | MAPTAPPSNCAKDM4ENPC1 | |
| SCHEMBL24705959 | 0.81 | DYRK1A (0.53) | MAPTKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL24426106 | 0.79 | NPC1 (0.58) | MAPTAPPSNCAKDM4ENPC1 | |
| SCHEMBL2628262 | 0.78 | APP (1.00) | MAPTAPPSNCAKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150056160-A1 | CHEMICALLY INDUCED INTRACELLULAR HYPERTHERMIA | TEXAS PHARMACEUTICALS, INC. | 2015-02-26 | — | — | US | claimed |
| US-20150056160-A1 | CHEMICALLY INDUCED INTRACELLULAR HYPERTHERMIA | TEXAS PHARMACEUTICALS, INC. | 2015-02-26 | — | — | US | disclosed |
| US-7635722-B1 | Chemical induced intracellular hyperthermia | Saint Jude Pharmaceuticals, Inc. (US) | 2009-12-22 | — | — | US | disclosed |
| EP-0412211-A1 | Cancer therapy system | THERAPEUTICAL SYSTEMS CORPORATION (US) | 1991-02-13 | — | — | EP | disclosed |
| US-4935450-A | Cancer therapy system for effecting oncolysis of malignant neoplasms | THERAPEUTICAL SYSTEMS CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |
| US-4724234-A | ADMINISTERING NUTRITIONAL REGIMEN AND AGENTS WHICH UNCOUPLE OXIDATIVE PHOSPHORYLATION | THERAPEUTICAL SYSTEMS CORP. (US) | 1988-02-09 | — | — | US | disclosed |