Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445126 | 0.89 | EGFR (0.67) | EGFRKCNH2 | |
| SCHEMBL4443366 | 0.88 | EGFR (0.70) | EGFRKCNH2 | |
| SCHEMBL4447535 | 0.85 | EGFR (0.69) | EGFRERBB2 | |
| SCHEMBL4448558 | 0.85 | EGFR (0.74) | EGFR | |
| SCHEMBL4449173 | 0.85 | EGFR (0.71) | EGFRERBB2 | |
| SCHEMBL4441265 | 0.85 | EGFR (0.79) | EGFRKCNH2ERBB2 | |
| SCHEMBL4445028 | 0.84 | EGFR (0.75) | EGFRKCNH2 | |
| SCHEMBL4445180 | 0.84 | EGFR (0.79) | EGFRKCNH2 | |
| SCHEMBL4445849 | 0.83 | EGFR (0.76) | EGFR | |
| Hydrochloric Acid SCHEMBL4447512 | 0.83 | EGFR (0.73) | EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632840-B2 | Quinazoline compounds for the treatment of hyperproliferative disorders | ASTRAZENECA AB (SE) | 2009-12-15 | — | — | US | disclosed |
| EP-1713781-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-20070293490-A1 | Quinazoline Derivatives | ASTRAZENECA AB (SE) | 2007-12-20 | — | — | US | disclosed |
| EP-1713781-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005075439-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293490-A1 | Quinazoline Derivatives | CCNA1, CCND3, CCND2 | EGFR 1579/4885KCNH2 2543/4885ERBB2 1807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.