Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.59 |
| ▸ | ABL1 | P00519 | 4/20 | 0.59 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.59 |
| ▸ | RAF1 | P04049 | 2/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | KIT | P10721 | 2/20 | 0.59 |
| ▸ | BCR | P11274 | 2/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.59 |
| ▸ | FLT1 | P17948 | 2/20 | 0.59 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.59 |
| ▸ | TTK | P33981 | 2/20 | 0.59 |
| ▸ | FLT4 | P35916 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.59 |
| ▸ | CLK1 | P49759 | 2/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.59 |
| ▸ | CDK17 | Q00537 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400258 | 0.91 | BRAF (0.70) | BRAFMAPK14ABL1RIPK1RAF1 | |
| SCHEMBL2245567 | 0.91 | MAPK14 (0.60) | BRAFMAPK14ABL1RIPK1RAF1 | |
| SCHEMBL2250309 | 0.89 | MAPK14 (0.57) | BRAFMAPK14ABL1RIPK1RAF1 | |
| SCHEMBL2240803 | 0.84 | MAPK14 (0.66) | BRAFMAPK14ABL1RIPK1RAF1 | |
| SCHEMBL1129422 | 0.84 | BRAF (0.74) | BRAFMAPK14ABL1RIPK1RAF1 | |
| SCHEMBL2241987 | 0.84 | ABL1 (0.78) | BRAFMAPK14ABL1RIPK1RAF1 | |
| SCHEMBL1129786 | 0.84 | BRAF (0.71) | BRAFMAPK14ABL1RIPK1RAF1 | |
| SCHEMBL2243621 | 0.83 | MAPK14 (0.52) | BRAFMAPK14ABL1RIPK1RAF1 | |
| SCHEMBL2241256 | 0.83 | ABL1 (0.62) | BRAFMAPK14ABL1RIPK1RAF1 | |
| SCHEMBL2242931 | 0.83 | MAPK14 (0.68) | BRAFMAPK14ABL1RIPK1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044053-A2 | UREA COMPOUNDS USEFUL IN THE TREATMENT OF CANCER | Bayer Healthcare, LLC (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2007064872-A2 | UREA COMPOUNDS USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | claimed |