Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988375 | 0.68 | PTGS1 (0.39) | HDAC4HDAC2HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL5272843 | 0.68 | SMN1; SMN2 (0.37) | HDAC4HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL10077162 | 0.68 | — | — | |
| SCHEMBL2919621 | 0.67 | HDAC4 (0.39) | HDAC4HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL28290161 | 0.67 | EPHX1 (0.37) | HDAC4HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL11615938 | 0.67 | PTGS1 (0.38) | HDAC4HDAC2HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL3901052 | 0.66 | — | — | |
| SCHEMBL3526537 | 0.66 | — | — | |
| SCHEMBL3317982 | 0.66 | — | — | |
| SCHEMBL953641 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124568-A1 | DECAHYDROQUINOLINE ANALOGS AS CB2 RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008088744-A1 | DECAHYDROQUINOLINE ANALOGS AS CB2 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |