Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435621 | 0.91 | FFAR1 (0.41) | KDM4EHSD17B10MEN1KMT2ABRAF | |
| SCHEMBL1825088 | 0.88 | KDM4E (0.49) | KDM4EHSD17B10MEN1KMT2ABRAF | |
| SCHEMBL1826748 | 0.87 | KDM4E (0.50) | KDM4EHSD17B10BRAFKDRACHE | |
| SCHEMBL1826874 | 0.86 | KMT2A (0.49) | KDM4EMEN1KMT2AHPGDMPO | |
| SCHEMBL1827641 | 0.86 | KDM4E (0.51) | KDM4EHSD17B10MEN1KMT2ABRAF | |
| SCHEMBL1827618 | 0.85 | SRD5A2 (0.47) | KDM4EHPGDMAPT | |
| SCHEMBL1827139 | 0.85 | PPARD (0.43) | KDM4EMEN1KMT2AHPGDMPO | |
| SCHEMBL1824122 | 0.81 | KDM4E (0.49) | KDM4EHSD17B10MEN1KMT2ABRAF | |
| SCHEMBL1826827 | 0.80 | KDM4E (0.50) | KDM4EHSD17B10MEN1KMT2ABRAF | |
| SCHEMBL4446018 | 0.80 | KDR (0.42) | KDM4EHSD17B10MEN1KMT2ABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118051-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | Chelsea Therapeutics, Inc. (US) | 2009-11-18 | — | — | EP | claimed |
| WO-2008097180-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | CHELSEA THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | claimed |