Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 12/20 | 0.41 |
| ▸ | BRAF | P15056 | 7/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448040 | 0.91 | KMT2A (0.43) | KMT2AKDRBRAFKCNA3MEN1 | |
| SCHEMBL4448047 | 0.91 | KMT2A (0.43) | KMT2AKDRBRAFKCNA3MEN1 | |
| SCHEMBL1823180 | 0.85 | KMT2A (0.43) | KMT2AKDRMEN1TSHRDHODH | |
| SCHEMBL1822975 | 0.85 | KMT2A (0.43) | KMT2AKDRMEN1TSHRDHODH | |
| SCHEMBL1822942 | 0.82 | KMT2A (0.51) | KMT2AKCNA3MEN1DHODHMGLL | |
| SCHEMBL1822945 | 0.82 | KMT2A (0.51) | KMT2AKCNA3MEN1DHODHMGLL | |
| SCHEMBL1825545 | 0.80 | KMT2A (0.43) | KMT2AMEN1TSHRDHODH | |
| SCHEMBL1823194 | 0.80 | KMT2A (0.43) | KMT2AMEN1TSHRDHODH | |
| SCHEMBL1823816 | 0.79 | KMT2A (0.44) | KMT2AKDRBRAF | |
| SCHEMBL1823818 | 0.79 | KMT2A (0.44) | KMT2AKDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118051-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | Chelsea Therapeutics, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008097180-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | CHELSEA THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |