Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 11/20 | 0.71 |
| ▸ | SRD5A2 | P31213 | 8/20 | 0.71 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | FNTA | P49354 | 3/20 | 0.52 |
| ▸ | FNTB | P49356 | 3/20 | 0.52 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457361 | 0.88 | SRD5A1 (0.69) | SRD5A1SRD5A2INPP5DCYP2D6CYP2C19 | |
| SCHEMBL4636876 | 0.87 | SRD5A1 (0.68) | SRD5A1SRD5A2INPP5DCYP2D6CYP2C19 | |
| SCHEMBL4636228 | 0.87 | SRD5A1 (0.68) | SRD5A1SRD5A2INPP5DCYP2D6CYP2C19 | |
| SCHEMBL8586967 | 0.86 | SRD5A1 (0.67) | SRD5A1SRD5A2INPP5DCYP2D6CYP2C19 | |
| SCHEMBL4635876 | 0.85 | SRD5A1 (0.65) | SRD5A1SRD5A2INPP5DFNTAFNTB | |
| SCHEMBL8965032 | 0.83 | SRD5A1 (1.00) | SRD5A1SRD5A2CYP2D6CYP2C19FNTA | |
| SCHEMBL17817402 | 0.83 | SRD5A1 (1.00) | SRD5A1SRD5A2CYP2D6CYP2C19FNTA | |
| SCHEMBL8965030 | 0.83 | SRD5A1 (1.00) | SRD5A1SRD5A2CYP2D6CYP2C19FNTA | |
| SCHEMBL1290265 | 0.82 | SRD5A1 (0.73) | SRD5A1SRD5A2INPP5DCYP2D6CYP2C19 | |
| SCHEMBL17817528 | 0.80 | CYP2D6 (0.60) | SRD5A1SRD5A2INPP5DCYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1865955-A4 | METHOD OF TREATING MEN WITH TESTOSTERONE SUPPLEMENT AND 5ALPHA-REDUCTASE INHIBITOR | MERCK & CO INC (US) | 2009-04-15 | — | — | EP | disclosed |
| EP-1865955-A2 | METHOD OF TREATING MEN WITH TESTOSTERONE SUPPLEMENT AND 5ALPHA-REDUCTASE INHIBITOR | Merck & Co., Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006104762-A2 | METHOD OF TREATING MEN WITH TESTOSTERONE SUPPLEMENT AND 5ALPHA-REDUCTASE INHIBITOR | MERCK & CO., INC. (US) | 2006-10-05 | — | — | WO | disclosed |