Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441603 | 0.91 | BRD4 (0.33) | HTR1ASLC6A2SLC6A4SLC6A3POLB | |
| SCHEMBL4437639 | 0.89 | JAK3 (0.37) | — | |
| SCHEMBL4437532 | 0.79 | JAK3 (0.37) | — | |
| SCHEMBL3490306 | 0.75 | CNR1 (0.36) | MEN1KMT2AHDAC1 | |
| SCHEMBL4440002 | 0.66 | JAK1 (0.39) | — | |
| SCHEMBL3490615 | 0.66 | CNR1 (0.37) | MEN1KMT2AHDAC1 | |
| SCHEMBL3490469 | 0.66 | AKT2 (0.45) | — | |
| SCHEMBL3491075 | 0.64 | CNR1 (0.36) | HTR1ASLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL3175163 | 0.64 | BRD4 (0.63) | MEN1KMT2A | |
| SCHEMBL29863128 | 0.64 | PDPK1 (0.38) | POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125805-A1 | SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY | Astex Therapeutics Limited (GB) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075109-A1 | SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY | ASTEX THERAPEUTICS LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |