Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 1.00 |
| ▸ | CCND1 | P24385 | 20/20 | 1.00 |
| ▸ | CCND3 | P30281 | 11/20 | 1.00 |
| ▸ | CCND2 | P30279 | 10/20 | 1.00 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.80 |
| ▸ | CDK2 | P24941 | 8/20 | 0.80 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.80 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.80 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.80 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.80 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.80 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.73 |
| ▸ | CDK9 | P50750 | 2/20 | 0.73 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.73 |
| ▸ | CDK16 | Q00536 | 2/20 | 0.73 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.73 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.73 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 2/20 | 0.73 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29507528 | 1.00 | CDK4 (1.00) | CDK4CCND1CCND3CCND2CCNA2 | |
| Hydrochloric Acid SCHEMBL4830666 | 0.99 | CDK4 (1.00) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL29507452 | 0.93 | CDK4 (0.87) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL4826062 | 0.93 | CDK4 (0.87) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL15874796 | 0.92 | CDK4 (0.86) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL4828621 | 0.92 | CDK4 (0.85) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL30176501 | 0.92 | CDK4 (0.85) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL22164964 | 0.91 | CDK4 (0.83) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL4828461 | 0.90 | CDK4 (0.81) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL29507484 | 0.90 | CDK4 (0.81) | CDK4CCND1CCND3CCND2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114245753-A | Combination of an anti-HER 2 antibody and a CDK inhibitor for tumor therapy | 江苏康宁杰瑞生物制药有限公司 | 2022-03-25 | — | — | CN | claimed |
| EP-1470124-B1 | 2-(PYRIDIN-2-YLAMINO)-PYRIDO 2,3-d]PYRIMIDIN-7-ONES | WARNER LAMBERT CO (US) | 2005-12-28 | — | — | EP | claimed |
| US-20050137214-A1 | 2-(Pyridin-2-ylamino)-pyrido [2,3-D]pyrimidin-7-ones | WARNER-LAMBERT COMPANY | 2005-06-23 | — | — | US | claimed |
| US-20030149001-A1 | 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones | BARVIAN MARK (US) | 2003-08-07 | — | — | US | claimed |
| US-20230118053-A1 | COMBINATION OF ANTI-HER2 ANTIBODY AND CDK INHIBITIOR FOR TUMOR TREATMENT | JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO., LTD. (CN) | 2023-04-20 | — | — | US | disclosed |
| CN-114245753-A | Combination of an anti-HER 2 antibody and a CDK inhibitor for tumor therapy | 江苏康宁杰瑞生物制药有限公司 | 2022-03-25 | — | — | CN | disclosed |
| US-20180250400-A1 | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK4/6 Inhibitor | ACERTA PHARMA BV (NL) | 2018-09-06 | — | — | US | disclosed |
| US-20180087079-A1 | METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE | AMGEN INC. (US) | 2018-03-29 | — | — | US | disclosed |
| US-20170224819-A1 | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK 4/6 Inhibitor | ACERTA PHARMA BV (NL) | 2017-08-10 | — | — | US | disclosed |
| WO-2016024232-A1 | THERAPEUTIC COMBINATIONS OF A BTK INHIBITOR, A PI3K INHIBITOR, A JAK-2 INHIBITOR AND/OR A CDK 4/6 INHIBITOR | ACERTA PHARMA B.V. (NL) | 2016-02-18 | — | — | WO | disclosed |
| US-20150353542-A1 | METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE | AMGEN INC. (US) | 2015-12-10 | — | — | US | disclosed |
| WO-2014109858-A1 | METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE | AMGEN INC. (US) | 2014-07-17 | — | — | WO | disclosed |
| EP-1470124-B1 | 2-(PYRIDIN-2-YLAMINO)-PYRIDO 2,3-d]PYRIMIDIN-7-ONES | WARNER LAMBERT CO (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2005094830-A1 | COMBINATIONS OF SIGNAL TRANSDUCTION INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | disclosed |
| US-20050222163-A1 | Combinations of signal transduction inhibitors | PFIZER INC | 2005-10-06 | — | — | US | disclosed |
| US-6936612-B2 | 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones | WARNER-LAMBERT COMPANY (US) | 2005-08-30 | — | — | US | disclosed |
| US-20050137214-A1 | 2-(Pyridin-2-ylamino)-pyrido [2,3-D]pyrimidin-7-ones | WARNER-LAMBERT COMPANY | 2005-06-23 | — | — | US | disclosed |
| EP-1470124-A1 | 2-(PYRIDIN-2-YLAMINO)-PYRIDO 2,3-d]PYRIMIDIN-7-ONES | Warner-Lambert Company LLC (US) | 2004-10-27 | — | — | EP | disclosed |
| US-20030149001-A1 | 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones | BARVIAN MARK (US) | 2003-08-07 | — | — | US | disclosed |
| WO-2003062236-A1 | 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY LLC (US) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149001-A1 | 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones | CDK4, CDK2, CDK1 | CDK4 1/4885CCND1 27/4885CCND3 44/4885 |
| US-20230118053-A1 | COMBINATION OF ANTI-HER2 ANTIBODY AND CDK INHIBITIOR FOR TUMOR TREATMENT | CDK6, CDK4, CDK2 | CDK4 2/4885CCND1 55/4885CCND3 66/4885 |
| US-20180250400-A1 | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK4/6 Inhibitor | BTK, JAK2, CDK4 | CDK4 3/4885CCND1 64/4885CCND3 70/4885 |
| US-20170224819-A1 | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK 4/6 Inhibitor | BTK, CDK6, CDK4 | CDK4 3/4885CCND1 73/4885CCND3 79/4885 |
| US-20050137214-A1 | 2-(Pyridin-2-ylamino)-pyrido [2,3-D]pyrimidin-7-ones | CDK4, CDK2, CDK3 | CDK4 1/4885CCND1 34/4885CCND3 46/4885 |
| US-20180087079-A1 | METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE | CDKN1A, CDC25C, CDC25B | CDK4 18/4885CCND1 52/4885CCND3 58/4885 |
| US-20050222163-A1 | Combinations of signal transduction inhibitors | CDK4, CDK3, CDK2 | CDK4 1/4885CCND1 66/4885CCND3 103/4885 |
| US-20150353542-A1 | METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE | CDKN1A, CDC25C, CDC25B | CDK4 18/4885CCND1 52/4885CCND3 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.