Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MOK | Q9UQ07 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138442 | 0.94 | HDAC1 (0.49) | ABL1BACE1HDAC1MAPTTHRB | |
| SCHEMBL4137652 | 0.94 | ABL1 (0.46) | ABL1BACE1HDAC1MAPTTHRB | |
| SCHEMBL4438905 | 0.93 | BACE1 (0.45) | ABL1BACE1MAPTTHRBRXFP1 | |
| SCHEMBL4138326 | 0.93 | HDAC1 (0.48) | ABL1BACE1HDAC1MAPTTHRB | |
| SCHEMBL4132202 | 0.91 | BACE1 (0.47) | ABL1BACE1HDAC1MAPTTHRB | |
| SCHEMBL4133042 | 0.89 | BACE1 (0.46) | ABL1BACE1HDAC1MAPTTHRB | |
| SCHEMBL4150218 | 0.89 | BACE1 (0.45) | ABL1BACE1MAPTTHRBRXFP1 | |
| SCHEMBL4141916 | 0.88 | BACE1 (0.45) | ABL1BACE1HDAC1MAPTTHRB | |
| SCHEMBL4150494 | 0.88 | BACE1 (0.45) | ABL1BACE1HDAC1MAPTTHRB | |
| SCHEMBL4142723 | 0.87 | BACE1 (0.43) | ABL1BACE1HDAC1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134695-A1 | INHIBITORS OF THE HEDGEHOG PATHWAY | Exelixis, Inc. (US) | 2009-12-23 | — | — | EP | claimed |
| WO-2008112913-A1 | INHIBITORS OF THE HEDGEHOG PATHWAY | EXELIXIS, INC. (US) | 2008-09-18 | — | — | WO | claimed |