Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.63 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.60 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.60 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29467164 | 1.00 | CHRM1 (0.63) | CHRM1CHRM2CHRM4CHRM3OPRM1 | |
| Hydrochloric Acid SCHEMBL31285831 | 0.98 | CHRM1 (0.62) | CHRM1CHRM2CHRM4CHRM3OPRM1 | |
| Ammonia Solution, Strong SCHEMBL1763968 | 0.98 | CHRM1 (0.62) | CHRM1CHRM2CHRM4CHRM3OPRM1 | |
| Hydrochloric Acid SCHEMBL7295362 | 0.98 | CHRM1 (0.62) | CHRM1CHRM2CHRM4CHRM3OPRM1 | |
| SCHEMBL3710702 | 0.92 | CHRM1 (0.78) | CHRM1CHRM2CHRM4CHRM3OPRM1 | |
| SCHEMBL2636603 | 0.91 | CHRM1 (0.57) | CHRM1CHRM2CHRM4CHRM3OPRM1 | |
| SCHEMBL2636477 | 0.91 | CHRM1 (0.57) | CHRM1CHRM2CHRM4CHRM3OPRM1 | |
| SCHEMBL2636476 | 0.91 | CHRM1 (0.57) | CHRM1CHRM2CHRM4CHRM3OPRM1 | |
| Hydrochloric Acid SCHEMBL5482985 | 0.90 | CHRM1 (0.76) | CHRM1CHRM2CHRM4CHRM3OPRM1 | |
| SCHEMBL319049 | 0.90 | CHRM1 (0.70) | CHRM1CHRM2CHRM4CHRM3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1074 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853392-B2 | Benzamide mGluR5 positive allosteric modulators and methods of making and using same | VANDERBILT UNIVERSITY (US) | 2014-10-07 | — | — | US | claimed |
| EP-2357172-B1 | Process for the preparation of pimozide | INST UNIV CIENCIA I TECNOLOGIA (ES) | 2012-10-31 | — | — | EP | claimed |
| EP-2394997-A1 | PROCESS FOR PREPARING 1-(4-PIPERIDINYL)BENZIMIDAZOLONE DERIVATIVES | Mitsubishi Tanabe Pharma Corporation (JP) | 2011-12-14 | — | — | EP | claimed |
| US-20110295013-A1 | PROCESS FOR PREPARING 1-(4-PIPERIDINYL)BENZIMIDAZOLONE DERIVATIVES | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-12-01 | — | — | US | claimed |
| EP-2357172-A1 | Process for the preparation of pimozide | Institut Univ. de Ciència i Tecnologia, S.A. (ES) | 2011-08-17 | — | — | EP | claimed |
| US-20100173941-A1 | Muscarinic Receptor Agonists that are Effective in the Treatment of Pain, Alzheimer's Disease and Schizophrenia | ASTRAZENECA AB (SE) | 2010-07-08 | — | — | US | claimed |
| EP-2132175-A2 | PROCESS FOR THE PREPARATION OF LOPERAMIDE | Institut Universitari de Ciència i Tecnologia (ES) | 2009-12-16 | — | — | EP | claimed |
| EP-1558595-B1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-25 | — | — | EP | claimed |
| EP-2035407-A1 | MUSCARINIC RECEPTOR AGONISTS THAT ARE EFFECTIVE IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | AstraZeneca AB (SE) | 2009-03-18 | — | — | EP | claimed |
| WO-2008080601-A2 | PROCESS FOR THE PREPARATION OF LOPERAMIDE | INSTITUT UNIVERSITARI DE CIÈNCIA I TECNOLOGIA (ES) | 2008-07-10 | — | — | WO | claimed |
| US-5571921-A | AMINATION OF PIPERIDINE DERIVATIVES BY DEHYDROHALOGENATION | BAYER AKTIENGESELLSCHAFT (DE) | 1996-11-05 | — | — | US | claimed |
| EP-0739891-A2 | Substituted heterocycles | ZENECA LIMITED (GB) | 1996-10-30 | — | — | EP | claimed |
| US-5563014-A | SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT | XEROX CORPORATION (US) | 1996-10-08 | — | — | US | claimed |
| US-5514505-A | SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE | XEROX CORPORATION (US) | 1996-05-07 | — | — | US | claimed |
| EP-0673783-A2 | Recording sheets containing purine, pyrimidine, benzimidazole, imidazolidine, urazole, pyrazole, triazole, benzotriazole, tetrazole, and pyrazine compounds | XEROX CORPORATION (US) | 1995-09-27 | — | — | EP | claimed |
| WO-1995016682-A1 | CYCLIC AMIDE DERIVATIVES AS NEUROKININ A ANTAGONISTS | ZENECA LIMITED (GB) | 1995-06-22 | — | — | WO | claimed |
| EP-0628555-A1 | Substituted (2-oxo-1-benzimidazolinyl)-piperidines, process for their preparation and their use as antiretroviral agents | BAYER AG (DE) | 1994-12-14 | — | — | EP | claimed |
| EP-0322396-A1 | Benzimidazole derivatives, their preparation and use | Gerot-Pharmazeutika Gesellschaft m.b.H. (AT) | 1989-06-28 | — | — | EP | claimed |
| EP-0091511-A2 | 1-(3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and -piperidines, a process for the preparation thereof, pharmaceutical compositions containing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-10-19 | — | — | EP | claimed |
| WO-1980000152-A1 | 3-AMINOPROPOXY-ARYL DERIVATES,PREPARATION AND USE THEREOF | SANDOZ AG (CH) | 1980-02-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173941-A1 | Muscarinic Receptor Agonists that are Effective in the Treatment of Pain, Alzheimer's Disease and Schizophrenia | CHRM1, CHRM2, CHRM5 | CHRM1 1/4885CHRM2 2/4885CHRM4 4/4885 |
| US-20110295013-A1 | PROCESS FOR PREPARING 1-(4-PIPERIDINYL)BENZIMIDAZOLONE DERIVATIVES | HDAC4, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HDAC2 | CHRM1 2144/4885CHRM2 3381/4885CHRM4 2996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.