Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.51 |
| ▸ | MTOR | P42345 | 5/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | STK4 | Q13043 | 1/20 | 0.49 |
| ▸ | STK3 | Q13188 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442229 | 0.92 | PIK3CA (0.53) | KDM4EHTTPIK3CAMTORPIK3CG | |
| SCHEMBL4449716 | 0.88 | PIK3CA (0.67) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| SCHEMBL31061290 | 0.88 | PIK3CA (0.67) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| SCHEMBL4998903 | 0.87 | PIK3CA (0.67) | KDM4EHTTPIK3CAMTORPIK3CG | |
| SCHEMBL4443377 | 0.86 | PIK3CA (0.70) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| SCHEMBL4440268 | 0.86 | PIK3CA (0.62) | PIK3CAMTORPIK3CGLMNASTK4 | |
| SCHEMBL4442909 | 0.84 | PIK3CA (0.69) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| SCHEMBL4443667 | 0.84 | PIK3CA (0.68) | PIK3CAMTORPIK3CGLMNASTK4 | |
| SCHEMBL4442257 | 0.83 | PIK3CA (0.71) | KDM4EPIK3CAMTORPIK3CGLMNA | |
| SCHEMBL4449028 | 0.83 | GAA (0.59) | KDM4EGAAPIK3CAMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101730697-A | Imidazopyrimidine analogs and their use as PI3 kinase and MTOR inhibitors | WYETH CORP | 2010-06-09 | — | — | CN | claimed |
| EP-2125815-A2 | IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008116129-A2 | IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS | WYETH (US) | 2008-09-25 | — | — | WO | claimed |
| US-20080233127-A1 | IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | claimed |
| CN-101730697-A | Imidazopyrimidine analogs and their use as PI3 kinase and MTOR inhibitors | WYETH CORP | 2010-06-09 | — | — | CN | disclosed |
| US-20080233127-A1 | IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080233127-A1 | IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS | MTOR, RICTOR, MTMR1 | KDM4E 2536/4885GAA 510/4885HTT 883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.