Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.47 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
| ▸ | CD38 | P28907 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1038335 | 0.83 | AAK1 (0.61) | AAK1CYP19A1CYP11B1CYP11B2PSEN1 | |
| SCHEMBL3312814 | 0.81 | CYP19A1 (0.55) | AAK1CYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL4456548 | 0.81 | PSEN1 (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17783138 | 0.80 | AAK1 (1.00) | AAK1 | |
| SCHEMBL3316441 | 0.80 | KMT2A (0.56) | AAK1POLBHTTKDM4ENPC1 | |
| SCHEMBL16388652 | 0.80 | AAK1 (1.00) | AAK1 | |
| SCHEMBL9290092 | 0.79 | CYP11B1 (0.61) | AAK1CYP19A1CYP11B1CYP11B2PSEN1 | |
| SCHEMBL3313160 | 0.78 | AAK1 (0.53) | AAK1CYP19A1CYP11B1CYP11B2PSEN1 | |
| SCHEMBL27159848 | 0.77 | CYP11B1 (0.60) | AAK1CYP19A1CYP11B1CYP11B2PSEN1 | |
| SCHEMBL3313965 | 0.77 | AAK1 (0.55) | AAK1CYP19A1CYP11B1CYP11B2QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2019093-A1 | UREA TYPE CINNAMIDE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2009-01-28 | — | — | EP | disclosed |