Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.40 |
| ▸ | JAK1 | P23458 | 11/20 | 0.40 |
| ▸ | JAK3 | P52333 | 11/20 | 0.40 |
| ▸ | TYK2 | P29597 | 9/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | MARK3 | P27448 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | FLT4 | P35916 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1135023 | 0.90 | JAK3 (0.41) | JAK2JAK1JAK3TYK2CSNK1D | |
| SCHEMBL1135047 | 0.90 | JAK2 (0.44) | JAK2JAK1JAK3TYK2FGFR1 | |
| SCHEMBL1134973 | 0.82 | JAK2 (0.46) | JAK2JAK1JAK3TYK2FGFR1 | |
| SCHEMBL1134936 | 0.80 | JAK1 (0.42) | JAK2JAK1JAK3TYK2FGFR1 | |
| SCHEMBL1134939 | 0.79 | JAK2 (0.41) | JAK2JAK1JAK3TYK2FGFR1 | |
| SCHEMBL1134994 | 0.78 | FGFR4 (0.41) | JAK2JAK1JAK3TYK2FGFR1 | |
| SCHEMBL1134944 | 0.78 | JAK1 (0.43) | JAK2JAK1JAK3TYK2NTRK1 | |
| SCHEMBL12993599 | 0.77 | LYN (0.41) | FGFR1LYNSRCBTKKDR | |
| SCHEMBL1134977 | 0.77 | JAK2 (0.44) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL1134917 | 0.73 | KMT2A (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027123-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007134259-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-11-22 | — | — | WO | disclosed |