⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4831 | 0.70 | — | — | |
| SCHEMBL853433 | 0.70 | — | — | |
| SCHEMBL3586187 | 0.67 | — | — | |
| SCHEMBL9277569 | 0.67 | — | — | |
| Trimethylammonium SCHEMBL7036647 | 0.64 | — | — | |
| SCHEMBL3569572 | 0.64 | — | — | |
| SCHEMBL6351501 | 0.64 | — | — | |
| SCHEMBL10776231 | 0.64 | — | — | |
| SCHEMBL6686928 | 0.64 | — | — | |
| SCHEMBL27657265 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 181 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2799441-B1 | Processes for the convergent synthesis of calicheamicin derivatives | WYETH LLC (US) | 2018-04-18 | — | — | EP | claimed |
| US-20180016228-A1 | PROCESSES FOR THE CONVERGENT SYNTHESIS OF CALICHEAMICIN DERIVATIVES | WYETH LLC (US) | 2018-01-18 | — | — | US | claimed |
| US-9802890-B2 | Processes for the convergent synthesis of calicheamicin derivatives | WYETH LLC (US) | 2017-10-31 | — | — | US | claimed |
| CN-106146350-A | A kind of new method of synthesizing amino methylcarbamoyl oximino ester derivant | 华南理工大学 | 2016-11-23 | — | — | CN | claimed |
| US-20150315138-A1 | PROCESSES FOR THE CONVERGENT SYNTHESIS OF CALICHEAMICIN DERIVATIVES | WYETH LLC (US) | 2015-11-05 | — | — | US | claimed |
| EP-1987048-B1 | PROCESSES FOR THE CONVERGENT SYNTHESIS OF CALICHEAMICIN DERIVATIVES | WYETH LLC (US) | 2014-11-19 | — | — | EP | claimed |
| EP-2799441-A1 | Processes for the convergent synthesis of calicheamicin derivatives | Wyeth LLC (US) | 2014-11-05 | — | — | EP | claimed |
| US-20140081010-A1 | PROCESSES FOR THE CONVERGENT SYNTHESIS OF CALICHEAMICIN DERIVATIVES | WYETH LLC (US) | 2014-03-20 | — | — | US | claimed |
| US-8273862-B2 | Processes for the convergent synthesis of calicheamicin derivatives | WYETH LLC (US) | 2012-09-25 | — | — | US | claimed |
| CN-101389639-B | Convergent synthesis of calicheamicin derivatives | WYETH CORP | 2012-07-18 | — | — | CN | claimed |
| EP-0689845-B1 | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis | AMERICAN CYANAMID CO (US) | 2002-09-04 | — | — | EP | claimed |
| EP-0837698-B1 | METHODS FOR THE PREPARATION OF MONOMERIC CALICHEAMICIN DERIVATIVE/CARRIER CONJUGATES | AMERICAN CYANAMID CO (US) | 2001-08-16 | — | — | EP | claimed |
| US-5877296-A | REACTING DISULFIDE ANALOGS OF CALICHEAMICIN FAMILY WITH A CARRIER SUCH AS PROTEIN, PEPTIDE, MONO AND POLYCLONAL ANTIBODIES, THEIR ANTIGEN-RECOGNIZING FRAGMENTS AND CHEMICALLY OR GENETICALLY ENGINEERED COUNTERPARTS | AMERICAN CYANAMID COMPANY (US) | 1999-03-02 | — | — | US | claimed |
| US-5773001-A | ANTIGROWTH AGENTS | AMERICAN CYANAMID COMPANY (US) | 1998-06-30 | — | — | US | claimed |
| EP-0837698-A1 | METHODS FOR THE PREPARATION OF MONOMERIC CALICHEAMICIN DERIVATIVE/CARRIER CONJUGATES | American Cyanamid Company (US) | 1998-04-29 | — | — | EP | claimed |
| US-5714586-A | INCUBATING CALICHEAMICIN DERIVATIVE AND PROTEIN CARRIER WITH SOLVENTS AND CARBOXYLIC ACID, PURIFYING | AMERICAN CYANAMID COMPANY (US) | 1998-02-03 | — | — | US | claimed |
| US-5712374-A | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates | AMERICAN CYANAMID COMPANY (US) | 1998-01-27 | — | — | US | claimed |
| WO-1996040261-A1 | METHODS FOR THE PREPARATION OF MONOMERIC CALICHEAMICIN DERIVATIVE/CARRIER CONJUGATES | AMERICAN CYANAMID COMPANY (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0689845-A2 | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis | AMERICAN CYANAMID COMPANY (US) | 1996-01-03 | — | — | EP | claimed |
| EP-0417454-A2 | Reduced size LHRH analogs | ABBOTT LABORATORIES (US) | 1991-03-20 | — | — | EP | claimed |