Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | CDC25B | P30305 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.38 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.38 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.38 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | BLM | P54132 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | PTPRC | P08575 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4443898 | 0.97 | CDC25B (0.39) | AURKACDC25BAURKBCYP1A1CYP1A2 | |
| Phenol SCHEMBL11668511 | 0.81 | TDP1 (0.48) | AURKACDC25BAURKBCYP1A1CYP1A2 | |
| SCHEMBL11664840 | 0.78 | — | — | |
| SCHEMBL594152 | 0.70 | CDC25B (0.47) | AURKACDC25BAURKBCYP1A1CYP1A2 | |
| SCHEMBL10866768 | 0.69 | CDC25B (0.41) | AURKACDC25BAURKBCYP1A1CYP1A2 | |
| SCHEMBL28498261 | 0.67 | CDC25B (0.45) | AURKACDC25BAURKBCYP1A1CYP1A2 | |
| SCHEMBL12033671 | 0.65 | — | — | |
| SCHEMBL5536618 | 0.60 | AURKA (0.33) | AURKACDC25BAURKBCYP1A1CYP1A2 | |
| SCHEMBL3296419 | 0.60 | AURKA (0.33) | AURKACDC25BAURKBCYP1A1CYP1A2 | |
| SCHEMBL21871795 | 0.60 | AURKA (0.33) | AURKACDC25BAURKBCYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140378522-A1 | UNIFYING MECHANISM AND METHODS TO PREVENT CANCER AND NEURODEGENERATIVE DISEASES | PREVENTION, L.L.C. (US) | 2014-12-25 | — | — | US | disclosed |
| US-20090312391-A1 | UNIFYING MECHANISM AND METHODS TO PREVENT CANCER AND NEURODEGENERATIVE DISEASES | PREVENTION, L.L.C. (US) | 2009-12-17 | — | — | US | disclosed |
| US-20050164911-A1 | By administering N-Acetylcysteine (NAC), and/or melatonin; cancer diagnosis by detecting or determining the amount of dopamine metabolites; quinone reductase inducer, lipoic acid or salt, and/or resveratrol or salt may be co-administered | PREVENTION LLC | 2005-07-28 | — | — | US | disclosed |
| WO-2003077900-A1 | A UNIFYING MECHANISM AND METHODS TO PREVENT CANCER AND NEURODEGENERATIVE DISEASES | PREVENTION, L.L.C. (US) | 2003-09-25 | — | — | WO | disclosed |