⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9639817 | 1.00 | — | — | |
| SCHEMBL10885668 | 0.81 | EGFR (0.37) | — | |
| SCHEMBL27880894 | 0.81 | EGFR (0.37) | — | |
| SCHEMBL15597 | 0.78 | — | — | |
| SCHEMBL18315247 | 0.78 | — | — | |
| SCHEMBL110533 | 0.78 | — | — | |
| SCHEMBL15598 | 0.78 | — | — | |
| SCHEMBL22770085 | 0.78 | — | — | |
| SCHEMBL7522298 | 0.78 | EGFR (0.38) | — | |
| SCHEMBL8720918 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4061767-A | ANTIINFLAMMATORY, ANALGESIC | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-12-06 | — | — | US | claimed |
| US-7638142-B2 | Therapeutic composition for the treatment of dry eye syndrome | VITAMIN SCIENCE, INC. (US) | 2009-12-29 | — | — | US | disclosed |
| US-20070082065-A1 | Therapeutic composition for the treatment of dry eye syndrome | VITAMIN SCIENCE LLC | 2007-04-12 | — | — | US | disclosed |
| US-6335356-B1 | LEFLUNOMIDE IN SOLUTION OF SURFACTANT AND ALCOHOL; ANTIPROLIFERATIVE AND ANTICARCINOGENIC AGENTS | SUGEN, INC. | 2002-01-01 | — | — | US | disclosed |
| US-6331555-B1 | EVALUATING SUSCEPTIBILITY OF CANCER TO COMPOUNDS WHICH INHIBIT PLATELET DERIVED GROWTH FACTOR RECEPTOR ACTIVITY | UNIVERSITY OF CALIFORNIA | 2001-12-18 | — | — | US | disclosed |
| EP-0830145-B1 | FORMULATIONS COMPRISING LEFLUNOMIDE | SUGEN INC (US) | 2000-06-14 | — | — | EP | disclosed |
| EP-0804191-B1 | USE OF INHIBITORS OF PLATELET DERIVED GROWTH RECEPTOR FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF CANCERS | SUGEN INC (US) | 2000-05-17 | — | — | EP | disclosed |
| EP-0997153-A1 | Formulations for lipophilic compounds | Sugen, Inc. (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5990141-A | ADMINISTERING 5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID-N-(4-TRIFLUOROMETHYL)ANILIDE OR 2-CYANO-3-HYDROXY-N-(4-TRIFLUORO-METHYL)PHENYL-2-BUTENAMIDE; ANTITUMOR,-CARCINOGENIC AND PROLIFERATIVE AGENTS; KINASE INHIBITORS | SUGEN INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5958959-A | ADMINISTERING 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID-(4-TRIFLUOROMETHYL)ANILIDE OR 2-CYANO-3-HYDROXY-N-(4-(TRIFLUOROMETHYL)PHENYL)-2-BUTENAMIDE | SUGEN, INC. (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0326107-B1 | ANTIARTHRITIC BETA-CYCLOALKYL-BETA-OXOPROPIONITRILES | Bristol-Myers Squibb Company (US) | 1992-09-02 | — | — | EP | disclosed |
| EP-0413329-A2 | 5-Methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for the treatment of ocular diseases | ALCON LABORATORIES, INC. (US) | 1991-02-20 | — | — | EP | disclosed |
| EP-0413329-A2 | 5-Methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for the treatment of ocular diseases | ALCON LABORATORIES, INC. (US) | 1991-02-20 | — | — | EP | disclosed |
| EP-0413329-A2 | 5-Methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for the treatment of ocular diseases | ALCON LABORATORIES, INC. (US) | 1991-02-20 | — | — | EP | disclosed |
| US-4975462-A | Antiarthritic α-arylcarbamoyl cyanoacetic acid derivatives | BRISTOL-MYERS COMPANY (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0352812-A1 | Antiarthritic alpha-arylcarbamoyl cyanoacetic acid derivatives | Bristol-Myers Squibb Company (US) | 1990-01-31 | — | — | EP | disclosed |
| US-4888357-A | ANTIINFLAMMATORY AGENTS | BRISTOL-MYERS COMPANY (US) | 1989-12-19 | — | — | US | disclosed |
| EP-0326107-A1 | Antiarthritic beta-cycloalkyl-beta-oxopropionitriles | Bristol-Myers Squibb Company (US) | 1989-08-02 | — | — | EP | disclosed |
| US-4061767-A | ANTIINFLAMMATORY, ANALGESIC | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-12-06 | — | — | US | disclosed |
| US-4061767-A | ANTIINFLAMMATORY, ANALGESIC | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-12-06 | — | — | US | disclosed |