SCHEMBL4451502

SCHEMBL4451502

Cc1cnc2c(c1)nc(-c1ccncc1CCC(F)(F)C(F)F)n2C

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 3/20 0.35
AKT1 P31749 2/20 0.32
AKT2 P31751 2/20 0.32
POLB P06746 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
BRD4 O60885 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10249224 0.80 PDE10A (0.40) PDE10AAKT1AKT2POLBSMN1; SMN2
SCHEMBL10249255 0.80 POLB (0.38) PDE10AAKT1AKT2POLBSMN1; SMN2
SCHEMBL10249204 0.77 PDE10A (0.32) PDE10AAKT1AKT2POLBSMN1; SMN2
SCHEMBL10249232 0.75 BUB1 (0.39) PDE10AAKT1AKT2POLBSMN1; SMN2
SCHEMBL10248903 0.75 POLB (0.38) PDE10AAKT1AKT2POLBSMN1; SMN2
SCHEMBL4403186 0.75 PDE10A (0.40) PDE10AAKT1AKT2POLBSMN1; SMN2
SCHEMBL10252611 0.74 PDE10A (0.35) PDE10AAKT1AKT2POLBSMN1; SMN2
SCHEMBL10249078 0.74 POLB (0.34) PDE10AAKT1AKT2POLBSMN1; SMN2
SCHEMBL10284539 0.73 POLB (0.42) PDE10APOLBSMN1; SMN2
SCHEMBL116162 0.73 POLB (0.47) PDE10APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012057265-A1 PEST CONTROL COMPOSITION AND METHOD FOR CONTROLLING PESTS 住友化学株式会社 (JP) 2012-05-03 WO disclosed
WO-2012057273-A1 HARMFUL ANIMAL CONTROL COMPOSITION AND METHOD FOR CONTROLLING HARMFUL ANIMALS 住友化学株式会社 (JP) 2012-05-03 WO disclosed
WO-2012057264-A1 PEST CONTROL COMPOSITION AND METHOD FOR CONTROLLING PESTS 住友化学株式会社 (JP) 2012-05-03 WO disclosed
WO-2012057260-A1 PEST CONTROL COMPOSITION AND METHOD FOR CONTROLLING PESTS 住友化学株式会社 (JP) 2012-05-03 WO disclosed
WO-2012057268-A1 PEST CONTROL COMPOSITION AND METHOD FOR CONTROLLING PESTS 住友化学株式会社 (JP) 2012-05-03 WO disclosed
WO-2012057266-A1 PEST CONTROL COMPOSITION AND METHOD FOR CONTROLLING PESTS 住友化学株式会社 (JP) 2012-05-03 WO disclosed
WO-2012057269-A1 HARMFUL ANIMAL CONTROL COMPOSITION AND METHOD FOR CONTROLLING HARMFUL ANIMALS 住友化学株式会社 (JP) 2012-05-03 WO disclosed